PMID: 9534951Apr 16, 1998Paper

Role of gender and vascular endothelium in rat aorta response to 17 beta-estradiol

Canadian Journal of Physiology and Pharmacology
Y le TranC Forster

Abstract

Estrogen supplementation in postmenopausal women offers significant cardiovascular protection. The mechanism for this benefit is unclear but may be due to an interaction of estrogen with the blood vessel wall (vascular smooth muscle and endothelium). We examined the response of weight-matched female and male endothelium-intact and -denuded aortae to 17 beta-estradiol, its interaction with noradrenaline, and the effect of N-nitro-L-arginine. Estradiol produced relaxation responses that were significantly greater in female endothelium-intact preparations. This response was sensitive to N-nitro-L-arginine, while the response to 17 beta-estradiol in male endothelum-intact and both female and male endothelum-denuded preparations was resistant. Estradiol also inhibited contractions to noradrenaline, which was more pronounced in the female endothelium-intact aortic rings. These data imply that estradiol interacts preferentially with the female vascular endothelium, but there exists an endothelium-independent process that can also be activated in the male aorta. Further studies are warranted to elucidate these differential mechanisms.

References

Aug 1, 1992·Journal of the American College of Cardiology·J K WilliamsT B Clarkson
Sep 12, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Aug 1, 1995·The American Journal of Medicine·M VolterraniP Collins
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Oct 1, 1996·Hypertension·S TaddeiA Salvetti
Jul 25, 1996·European Journal of Pharmacology·A M McNeillD N Krause

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Citations

Sep 13, 2003·European Journal of Pharmacology·Patcharin Tep-areenanMichael D Randall
Aug 8, 2001·International Journal of Toxicology·B B Curry
Jul 19, 2001·Japanese Journal of Pharmacology·D A Pelligrino, E Galea

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