PMID: 9420475Jan 1, 1997Paper

Role of gene conversion in generating polymorphisms at major histocompatibility complex loci

Hereditas
T Ohta

Abstract

Multigene families are known to be evolving under continued occurrence of unequal crossing-over and gene conversion, and MHC loci are no exceptions. Population genetic models of diversifying selection, with intra- and inter-locus gene conversion were studied by computer simulations. Weak selection at individual amino acid site is shown to be quite effective in enhancing polymorphisms, if gene conversion occurs. This is caused by the appearance of coadapted segments of mutations in which recombination tends to be suppressed. In addition to the global type of diversifying selection, endemic type of selection was introduced in some sets of simulations to find out a mechanism of the rapid allelic turnover of South American Indians. Strong selection is assumed such that the most common two alleles become lethal in one generation. If this endemic selection occurs periodically, allelic turnover by intralocus gene conversion is shown to become rapid. Hence, interaction of selection and gene conversion has a profound effect on MHC polymorphisms.

References

Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T Ohta
Jul 1, 1991·Journal of Molecular Evolution·T Ohta
Jan 1, 1990·Annual Review of Immunology·D A LawlorP Parham
Apr 1, 1983·Theoretical Population Biology·T Ohta
Feb 1, 1995·Immunological Reviews·P ParhamK L Arnett
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y SattaJ Klein
Feb 1, 1996·Molecular Phylogenetics and Evolution·E A Thompson, J V Neel
May 8, 1997·Nature·P Hedrick

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Citations

Mar 7, 2009·Genetica·Hideki Innan
Jan 1, 2011·Genes·Jeffrey A Fawcett, Hideki Innan
Jan 16, 1999·Current Opinion in Biotechnology·J D Terwilliger, K M Weiss
Feb 27, 2008·BMC Genomics·Shuqing XuXiaoguang Zheng

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