Role of genes in oro-dental diseases

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
B KavithaT R Saraswathi

Abstract

In oral cavity, the spectrum of diseases due to genetic alterations ranges from developmental disturbances of teeth to the pre-cancerous and cancerous lesions. Of late, significant progress has been made in the molecular analysis of tumors. With molecular genetic testing emerging as diagnostic, prognostic, and therapeutic approach, a review of genetic alterations ranging from the development of oro-facial structures to the tumors in the head and neck region are addressed in this article. The functional regulatory aspect of genes in relation to oro-facial structures are discussed separately, i.e., in relation to tooth genesis, tooth agenesis (non-syndromic, syndromic), tooth structural alterations, syndromic oro-facial defects, bone diseases, skin diseases (genodermatoses), and malignant tumors. In this literature, various genes involved in the development of the oro-facial structures and tooth in particular are discussed. The genetic basis of disorders in the tooth development (agenesis, hypodontia), tooth structural defects like amelogenesis imperfecta (AI), dentinogenesis imperfecta (DI), and oro-facial structural alterations (various syndromes) are explained.

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Citations

Dec 14, 2012·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·S M Cudney, A R Vieira
Apr 22, 2011·In Vitro Cellular & Developmental Biology. Animal·Francisco Javier Gutiérrez-CantúAlma Lilián Guerrero-Barrera
Sep 14, 2013·European Journal of Oral Sciences·Adrianna MostowskaPaweł P Jagodziński
Dec 30, 2014·European Journal of Oral Sciences·Adrianna MostowskaPaweł P Jagodziński
Feb 3, 2012·Archives of Oral Biology·Adrianna MostowskaPawel P Jagodzinski
Aug 5, 2016·Archives of Oral Biology·Marwa Haddaji MastouriDorra H'mida Ben Brahim
Oct 5, 2016·Human Genetics·M PhanC E L Carels
Oct 11, 2017·Oral Diseases·A MostowskaP P Jagodziński
Jan 23, 2019·Minerva stomatologica·Daniele De SantisPier Francesco Nocini

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