Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer

Molecular Genetics and Metabolism
Anvesha SrivastavaBalraj Mittal

Abstract

Gallbladder carcinoma (GBC) usually arises in the background of gallstone disease. Cholesterol 7alpha-hydroxylase (CYP7A1) is a rate-limiting enzyme for cholesterol catabolism and bile acid synthesis. A-204C genetic polymorphism in CYP7A1 may influence gene expression and thus affect the risk of gallstone disease and GBC. We aimed to study the association of A-204C variation of CYP7A1 gene promoter polymorphism in GBC patients, gallstone patients and healthy subjects. The study included 141 histopathologically proven GBC patients, ultrasonographically proven 185 symptomatic gallstone patients and 200 gallstone-free healthy subjects. Genotyping was done by PCR-RFLP method. CYP7A1 A-204C genotypes in control population were in Hardy-Weinberg equilibrium. The CC genotype conferred marginally significant risk for gallstone disease (p=0.051; OR=1.54; 95% CI=0.9-3.4). In GBC patients, the CYP7A1 A-204C polymorphism conferred high risk for GBC at genotype (p=0.005; OR=2.78; 95% CI: 1.3-5.6) as well as allele levels (p=0.008; OR=1.58 and 95% CI: 1.1-2.2). After stratification of GBC patients on the basis of presence or absence of gallstones, CC genotype imparted higher risk for GBC without stones (p=0.002; OR=4.44: 95% CI=1.7-11.3). Th...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Nov 1, 1993·Breast Cancer Research and Treatment·P A Newcomb, P M Lantz
Aug 23, 2000·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M Pandey, V K Shukla
Jul 3, 2002·The Journal of Clinical Investigation·Clive R PullingerJohn P Kane
Sep 3, 2004·Nature Reviews. Cancer·Ignacio I Wistuba, Adi F Gazdar
Jun 9, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·S N PandeyB Mittal
Jul 14, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Manjusha DixitBalraj Mittal

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Citations

Jan 9, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Daniel W NebertWalter L Miller
Nov 21, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Anvesha SrivastavaBalraj Mittal
Feb 25, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Lingyu FuBo Zhou
Jun 28, 2017·World Journal of Gastroenterology : WJG·Aarti SharmaAshok Kumar
Sep 22, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Eda SezerOrhan Adalı
Oct 24, 2009·Neurobiology of Disease·Ho Jin KimHyoung Doo Shin

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