Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos

Ecotoxicology and Environmental Safety
Luna WangYan An

Abstract

Growth hormone (GH)/insulin-like growth factor (IGF) axis plays a critical role in fetal development. However, the effect of arsenite exposure on the GH/IGF axis and its toxic mechanism are still unclear. Zebrafish embryos were exposed to a range of NaAsO2 concentrations (0.0-10.0 mM) between 4 and 120 h post-fertilization (hpf). Development indexes of survival, malformation, hatching rate, heart rate, body length and locomotor behavior were measured. Hormone levels, GH/IGF axis-related genes, and nerve-related genes were also tested. The results showed that survival rate, hatching rate, heart rate, body length and locomotor behavior all decreased, while deformity increased. At 120 hpf, the survival rate of zebrafish in 1.5 mM NaAsO2 group was about 70%, the deformity rate exceeded 20%, and the body length shortened to 3.35 mm, the movement distance of zebrafish decreased approximately 63.6% under light condition and about 52.4% under dark condition. The level of GH increased and those of IGF did not change significantly, while the expression of GH/IGF axis related genes (ghra, ghrb, igf2r, igfbp3, igfbp2a, igfbp5b) and nerve related genes (dlx2, shha, ngn1, elavl3, gfap) decreased. In 1.5 mM NaAsO2 group, the decrease of igfbp...Continue Reading

References

Jan 1, 1989·Progress in Growth Factor Research·R C Baxter, J L Martin
May 10, 2003·Science·Ronald S Oremland, John F Stolz
May 3, 2005·General and Comparative Endocrinology·Manfred ReineckeJoaquim Gutiérrez
Jun 22, 2005·Toxicology and Applied Pharmacology·D N Guha Mazumder
Apr 1, 2006·Mutation Research·Soile Tapio, Bernd Grosche
Aug 26, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Christopher TonCatherine Willett
Jan 24, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Brian S ShepherdGregory M Weber
Feb 6, 2007·Environmental Health : a Global Access Science Source·Jaymie R MelikerJerome O Nriagu
Jul 26, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Walter H Watson, James D Yager
Aug 5, 2008·Chemico-biological Interactions·A VahidniaF A de Wolff
Mar 17, 2010·Gene Expression Patterns : GEP·Cecilia M Di PrinzioSilvia E Arranz
Jul 14, 2010·Environmental Health : a Global Access Science Source·Nurshad AliKhaled Hossain
Feb 26, 2013·Neural Development·Rebecca SchmidtSteffen Scholpp
Apr 25, 2013·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Philip G Murray, Peter E Clayton
Feb 11, 2015·Aquatic Toxicology·Oana BirceanuMathilakath M Vijayan
Oct 4, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Shoshana Yakar, Olle Isaksson
Dec 30, 2015·Toxicology and Applied Pharmacology·Manon C BouwmeesterLeo T M van der Ven
Apr 14, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mary O HuffCarolyn M Klinge
May 4, 2016·Zebrafish·Janell HallauerZijuan Liu
Jun 17, 2016·Toxicology and Applied Pharmacology·Yuji FuseMakoto Kobayashi
Oct 5, 2016·Environmental Toxicology and Chemistry·Scott GlabermanMace G Barron
Jul 12, 2017·Free Radical Biology & Medicine·Chang-Lin WuChristina L Chang
Nov 18, 2017·International Journal of Molecular Sciences·Vittorio Emanuele BianchiLaura Rizzi
Sep 16, 2018·Regulatory Toxicology and Pharmacology : RTP·M Sue MartyLeah M Zorrilla
Feb 20, 2019·International Journal of Molecular Sciences·Sandra VranicGaku Ichihara

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Citations

Mar 16, 2021·Frontiers in Endocrinology·Fritzie T Celino-BradyAndre P Seale

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