Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

International Journal of Molecular Sciences
Maja SabolSonja Levanat

Abstract

GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.

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Feb 14, 2019·Cells·Paweł NiewiadomskiKatarzyna Chojnowska
Mar 27, 2019·Future Medicinal Chemistry·Christian Espinosa-BustosCristian O Salas
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Jan 27, 2021·International Journal of Molecular Sciences·Sidney IrianaNeelam Sharma-Walia
Feb 4, 2021·Journal of Cellular Physiology·Dian JingJun Wang

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xenograft
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