Apr 1, 1982

Role of glnA-linked genes in regulation of glutamine synthetase and histidase formation in Klebsiella aerogenes

Journal of Bacteriology
N RothmanB Magasanik

Abstract

We isolated mutants of Klebsiella aerogenes with insertions of transposon Tn5 linked to the structural gene for glutamine synthetase, glnA. We found that K. aerogenes, like Escherichia coli and Salmonella typhimurium, contains a regulatory gene, glnG, which is closely linked to but distinct from glnA. The product of glnG is essential for normal regulation of the synthesis of glutamine synthetase and histidase. We analyzed two mutations which affected the regulation of the formation of these enzymes and appeared to be outside glnG. The results of our studies suggest the presence in K. aerogenes of at least two regulatory genes located in the glnA region, namely, glnG and another gene, the transcription of which can be initiated at the promoter of glnA.

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Mentioned in this Paper

Enzymes, antithrombotic
GLUL
Glutamate-Ammonia Ligase
GLUL gene
Promoter
Histidine Ammonia-Lyase
Enterobacter aerogenes bacterium
Genome Mapping
Ammonia-Lyases
Genes, Regulator

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