Role of glucocorticoids in the regulation of brain prostaglandin biosynthesis under basal conditions and in response to endotoxin

Endocrinology
J WeidenfeldE Shohami

Abstract

Glucocorticoids (GC) are known to inhibit eicosanoid production in various peripheral tissues; however, their role in the regulation of basal and induced prostaglandin (PG) biosynthesis in the brain is still not clear. In the present study we examined the effect of exogenous dexamethasone (dex) or endogenous GC on basal and on bacterial endotoxin (lipopolysaccharide, LPS) induced ex vivo production of PGE2 by the frontal cortex of rat brain. The experimental groups were: 1) intact rats; 2) rats in whom endogenous GC were removed either by surgical or by chemical (metopirone) adrenalectomy (adex); and 3) rats exposed to specific corticosteroid receptor antagonists. In intact rats, the basal rate of PGE2 ex vivo synthesis was about 120 pg/mg protein.hr; dex (0.05-0.5 mg/100 g body wt ip) did not affect this level. Exposure to LPS (50 micrograms, intracerebroventricular) induced a 2-fold increase in PGE2, whereas pretreatment with dex abolished this increase. Bilateral adex or metopirone alone did not change PGE2 synthesis, whereas LPS administration to surgical or chemical adex rats resulted in a 4-fold increase in PGE2 production. Administration (intracerebroventricular) of either one or both of the specific corticosteroid recep...Continue Reading

Citations

Sep 25, 2010·Peptides·Talia Filipovich-Rimon, Sigal Fleisher-Berkovich
Dec 1, 1995·Journal of Neurotrauma·E ShohamiJ Weidenfeld
Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·H OkamotoA G Hudetz
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B J MacNeilD M Nance
Jul 19, 2000·Journal of Neurochemistry·L F García-FernándezA Muñoz

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