Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
David H RootMarisela Morales


The ventral tegmental area (VTA) plays roles in both reward and aversion. The participation of VTA in diverse behaviors likely reflects its heterogeneous neuronal phenotypes and circuits. Recent findings indicate that VTA GABAergic neurons that coexpress tyrosine hydroxylase (TH) projecting to lateral habenula (LHb) play a role in reward. In addition to these mesohabenular TH-GABAergic neurons, the VTA has many neurons expressing vesicular glutamate transporter 2 (VGluT2) that also project to LHb. To determine the behavioral role of mesohabenular VGluT2 neurons, we targeted channelrhodopsin2 to VTA VGluT2 neurons of VGluT2::Cre mice. These mice were tested in an apparatus where moving into one chamber stimulated VTA VGluT2 projections within the LHb, and exiting the chamber inactivated the stimulation. We found that mice spent significantly less time in the chamber where VGluT2 mesohabenular fiber stimulation occurred. Mice that received injections of mixed AMPA and NMDA glutamate receptor antagonists in LHb were unresponsive to VGluT2-mesohabenular fiber stimulation, demonstrating the participation of LHb glutamate receptors in mesohabenular stimulation-elicited aversion. In the absence of light stimulation, mice showed a cond...Continue Reading


Jan 19, 2016·Frontiers in Psychiatry·Nora L Salaberry, Jorge Mendoza
Oct 28, 2015·FEBS Letters·Angela AndereggRajeshwar Awatramani
Jan 15, 2016·Journal of Chemical Neuroanatomy·David J BarkerMarisela Morales
Jan 18, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn FigeeDamiaan Denys
Sep 6, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elizabeth J BurnettHeather Trantham-Davidson
May 27, 2015·The Journal of Comparative Neurology·Mats Julius StensrudVidar Gundersen
Aug 16, 2015·Cell·Nora D Volkow, Marisela Morales
Aug 5, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Benjamin T SaundersPatricia H Janak
Apr 11, 2015·Progress in Neurobiology·David H RootT Celeste Napier
Feb 11, 2015·Nature Neuroscience·Shiliang ZhangMarisela Morales
May 29, 2016·The International Journal of Neuropsychopharmacology·Jing LiJiang Hong Ye
May 31, 2016·Neuron·Santhosh SethuramanujamGautam B Awatramani
Jun 23, 2016·Journal of Neurogenetics·Kristin M Scaplen, Karla R Kaun
Aug 20, 2016·Brain Structure & Function·Clémentine FillingerPierre Veinante
Nov 9, 2016·Frontiers in Synaptic Neuroscience·Anna TchenioManuel Mameli
Jul 20, 2016·PloS One·Elyssa B Margolis, Howard L Fields
Dec 16, 2016·Nature Communications·Ji Hoon YooThomas S Hnasko
Jan 6, 2017·Nature Reviews. Neuroscience·Marisela Morales, Elyssa B Margolis
Jun 26, 2017·Pharmacology, Biochemistry, and Behavior·Daniel S Zahm, David H Root
Aug 30, 2017·British Journal of Pharmacology·Taylor S ThomasStephanie L Borgland
May 21, 2018·The European Journal of Neuroscience·Can PengRyan M Drenan
Sep 5, 2018·Reviews in the Neurosciences·Marcus L Brandão, Norberto C Coimbra
Nov 25, 2018·The European Journal of Neuroscience·Eve H Limbrick-OldfieldMark A Ungless
Mar 13, 2019·The European Journal of Neuroscience·Mauro CongiuSalvatore Lecca
Jan 21, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kevin R CoffeyJohn F Neumaier
Apr 25, 2020·Addiction Biology·Jillienne C TouchetteAnna M Lee
Jul 21, 2020·Addiction Biology·Kaitlin C ReevesBrady K Atwood
Aug 30, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li MaJiu-Hong Kang
Jan 13, 2015·The European Journal of Neuroscience·Tsuyoshi YamaguchiMarisela Morales
Dec 12, 2018·Neuropsychology Review·Judy LuigjesDamiaan Denys
Nov 30, 2019·Science·András SzőnyiGábor Nyiri
Nov 7, 2019·Frontiers in Neurology·Wenjun WangXiang Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Thomas S HnaskoRobert H Edwards
The European Journal of Neuroscience
Tsuyoshi YamaguchiMarisela Morales
© 2021 Meta ULC. All rights reserved