Role of glutathione in plant signaling under biotic stress.

Plant Signaling & Behavior
Carole Dubreuil-Maurizi, Benoît Poinssot

Abstract

Glutathione (GSH) is a non-protein thiol compound which has been repeatedly reported to play an important role in plant responses during biotic stresses. However, our knowledge of glutathione-related molecular mechanisms underlying plant defense responses still remains limited. We first discovered that the Arabidopsis thaliana phytoalexin deficient 2-1 (pad2-1) mutant was linked to glutathione deficiency since the mutation was identified in the GSH1 gene encoding the first enzyme of glutathione biosynthesis: Glutamate Cysteine Ligase (GCL). Interestingly, this glutathione-deficient mutant pad2-1 also displays a high susceptibility to a wide range of invaders. We recently reported that the glutathione deficiency in pad2-1 is directly related to a low content of GCL protein. In parallel, we highlighted that the altered redox potential in pad2-1 upregulates the oxidative-stress marker genes GR1, GSTF6 and RbohD during infection with the hemibiotrophic oomycete Phytophthora brassicae. Moreover, the impairment of early signaling events such as plasma membrane depolarization, production of nitric oxide and reactive oxygen species also correlates with the reduced hypersensitive response (HR) observed during P. brassicae infection. Con...Continue Reading

References

Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·J Glazebrook, F M Ausubel
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Nov 10, 2011·The Plant Journal : for Cell and Molecular Biology·Varanavasiappan ShanmugamKuo-Chen Yeh

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Citations

Oct 2, 2013·Journal of Agricultural and Food Chemistry·Michela SchiavonMario Malagoli
Sep 4, 2015·The Plant Journal : for Cell and Molecular Biology·Varanavasiappan ShanmugamKuo-Chen Yeh
Oct 28, 2015·Horticulture Research·Kelly Mayrink BalmantSixue Chen
Apr 9, 2015·Frontiers in Plant Science·Ariel Herrera-VásquezLoreto Holuigue
Jun 9, 2016·International Journal of Molecular Sciences·Simone LutiLuigia Pazzagli
Apr 4, 2013·International Journal of Molecular Sciences·Lyuben ZagorchevMariela Odjakova
Dec 1, 2018·Antioxidants & Redox Signaling·Mirko ZaffagniniPaolo Trost
Jul 16, 2020·Antioxidants·Atefeh FarvardinBegonya Vicedo
Apr 24, 2019·International Journal of Molecular Sciences·Tomasa Quiterio-GutiérrezAntonio Juárez-Maldonado

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