Role of glutathione S-transferase Mu-1 (GSTM1) polymorphism in oligospermic infertile males

Andrologia
G Tirumala VaniP Pardhanandana Reddy

Abstract

The aim of this study was to examine whether an association exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and idiopathic male infertility. Forty-two men with infertility and 43 fertile men were recruited for this study. GSTM1 gene was analysed using PCR technique. The frequency of GSTM1 null (-) genotype was observed to be 45.2% in infertile men as against 20.09% in fertile men. Subjects with the GSTM1 null genotype had lower sperm concentrations and motility when compared with the subjects with GSTM1-positive genotype in both the groups. This study shows that the frequency of GSTM1 null (-) genotype is significantly high in infertile males when compared with the frequency in fertile males (OR = 0.32, P = 0.017, 95% CI = 0.124-0.831).

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Citations

May 25, 2012·Journal of Assisted Reproduction and Genetics·Wu ChengyongWen Xuezhen
Dec 15, 2012·Journal of Assisted Reproduction and Genetics·Xueru SongYuanjie Niu
May 2, 2013·Genetic Testing and Molecular Biomarkers·Hou-Qun YingZhou-Cun A
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Dec 7, 2019·Cellular and Molecular Life Sciences : CMLS·Marc LlavaneraMarc Yeste
Oct 6, 2017·Human Reproduction Update·Hagai LevineShanna H Swan
Mar 10, 2021·Andrologia·Fernando LopesRosário Pinto-Leite
Mar 19, 2021·Frontiers in Cell and Developmental Biology·Marc LlavaneraMarc Yeste

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