Role of glutathione S-transferases in detoxification of a polycyclic aromatic hydrocarbon, methylcholanthrene

Chemico-biological Interactions
Sreenivasulu DasariBalaji Meriga

Abstract

Glutathione S-transferases (GSTs), the versatile phase II biotransformation enzymes, metabolize and detoxify a wide variety of toxic chemical compounds like carcinogens, chemotherapeutic drugs, environmental pollutants and oxidative stress products. GSTs are currently of great interest in drug discovery, nanotechnology and biotechnology because of their involvement in many major cellular processes. GSTs, which are either homo or hetero dimeric proteins mediate catalytic binding between glutathione (GSH) and an array of either endogenous or exogenous toxic compounds to form a highly soluble detoxified complex which is then eliminated. Polycyclic aromatic hydrocarbons (PAHs) which are composed of two or more benzene rings bonded as linear, cluster or angular arrangements are used as intermediaries in pharmaceuticals, agricultural products, photographic products, thermosetting plastics, lubricating materials and other chemical products. Foods those cooked at high temperatures by grilling, roasting, frying and smoking are the main sources for the persistent bio-accumulation of PAHs in food chain. The carcinogenic, mutagenic and immunosuppressive effects of PAHs are well established. A well-known polycyclic aromatic hydrocarbon, met...Continue Reading

Citations

Feb 11, 2020·Frontiers in Microbiology·Jorge Carlos Navarro-Muñoz, Jérôme Collemare
Jul 16, 2020·Environmental Microbiology·Heidy Peidro-GuzmánRamón Alberto Batista-García
Jan 7, 2021·The Protein Journal·Kohji Yamamoto, Aiko Hirowatari
Jan 19, 2021·Journal of Global Antimicrobial Resistance·Busi ZhaoLi Wang
Jan 8, 2021·Biology of Reproduction·Kelli F Malott, Ulrike Luderer
Aug 14, 2020·Environmental Toxicology and Pharmacology·Caroline Santos, Claudia Bueno Dos Reis Martinez
Apr 23, 2021·Analytical Methods : Advancing Methods and Applications·Yi Chen
May 11, 2021·Current Allergy and Asthma Reports·Xin DaiCaroline Lodge

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