PMID: 2106010Mar 1, 1990Paper

Role of glycine in the N-methyl-D-aspartate-mediated neuronal cytotoxicity

Journal of Neurochemistry
J PatelA Salama

Abstract

Current evidence indicates that glutamate acting via the N-methyl-D-aspartate (NMDA) receptor/ion channel complex plays a major role in the neuronal degeneration associated with a variety of neurological disorders. In this report the role of glycine in NMDA neurotoxicity was examined. We demonstrate that NMDA-mediated neurotoxicity is markedly potentiated by glycine and other amino acids, e.g., D-serine. Putative glycine antagonists HA-966 and 7-chlorokynurenic acid were highly effective in preventing NMDA neurotoxicity, even in the absence of added glycine. The neuroprotective action of HA-966 and 7-chlorokynurenic acid, but not that of NMDA antagonists 3-(2-carboxypiperazine-4-yl)propylphosphonate and MK-801, could be reversed by glycine. These results indicate that glycine, operating through a strychinine-insensitive glycine site, plays a central permissive role in NMDA-mediated neurotoxicity.

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Citations

Jan 1, 1997·Journal of Neural Transmission·M NilssonM L Carlsson
Oct 19, 2004·Experimental Brain Research·A BarthD W Newell
Sep 29, 2007·European Archives of Psychiatry and Clinical Neuroscience·Seong S ShimBaik S Kee
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Jan 1, 1993·Schizophrenia Research·R WaziriA D Sherman
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Uriel Heresco-Levy
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Nov 27, 2009·Neurochemical Research·Jane P HughesStephen D Skaper
Feb 15, 2011·Drug and Chemical Toxicology·Guliz ArmaganAyfer Yalcin

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