Role of glycosaminoglycans (GAGs) in regulation of the immunogenicity of human vascular endothelial cells

Clinical and Experimental Immunology
D A RixJ A Kirby

Abstract

Heparan sulphate is a common glycosaminoglycan component of proteoglycans present on the luminal surface of vascular endothelium. It has been proposed that an important function of these molecules is the sequestration of a range of proinflammatory and proadhesive cytokines. Such cytokines play a vital role during lymphocyte recruitment from the blood at sites of inflammation. In this study it is shown that the effects of interferon-gamma (IFN-gamma), but not of tumour necrosis factor-alpha (TNF-alpha), are inhibited by treatment with soluble heparin. Specifically, heparin was shown to inhibit the induction of class II MHC antigens and the up-regulation of intercellular adhesion molecule-1 (ICAM-1) produced by treatment of cultured human endothelial cells with IFN-gamma. Furthermore, it was shown that heparin blocked the enhanced adhesion of T lymphocytes to IFN-gamma-treated endothelial cells. Investigation of the inhibitory effects of other GAG molecules demonstrated a requirement for heparin-like structural domains as chondroitin sulphate was unable to inhibit the function of IFN-gamma. These results may explain reported immunosuppressive properties of heparin, and are consistent with the model that heparin may compete with c...Continue Reading

Citations

Dec 28, 2007·Glycoconjugate Journal·Mohamad WardaJin Han
Apr 4, 2008·Molecular Medicine·Lars SteinstraesserTobias Hirsch
Aug 8, 2002·Thrombosis Research·Anthony W O'ReganJeffrey S Berman
Mar 12, 2005·Journal of the American Academy of Dermatology·Arash Izadpanah, Richard L Gallo
Jun 17, 2000·Cytokine·V Balasubramanian, M Ramanathan
Apr 29, 1998·Journal of the American Academy of Dermatology·M WalchnerM Röcken
Jun 30, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L RamdinJ K Shute
Feb 13, 2015·American Journal of Physiology. Renal Physiology·Martijn J C DaneTon J Rabelink
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ivan Rubio-GayossoBrian R Duling
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BrooksJ W Coleman
Feb 10, 2020·The American Journal of Pathology·Gangqi WangTon J Rabelink
Nov 5, 1997·Diabetes Research and Clinical Practice·J SkrhaA Oksa
Apr 18, 2003·Seminars in Arthritis and Rheumatism·Marco Matucci CerinicF Marongiu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.