Role of gonadal hormones in programming developmental changes in thymopoietic efficiency and sexual diergism in thymopoiesis

Immunologic Research
Gordana LeposavicIvan Pilipovic

Abstract

There is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually diergic changes in thymopoietic efficiency, which in rodents occur around puberty and lead to a substantial phenotypic and functional remodeling of the peripheral T-cell compartment. This in turn leads to an alteration in the susceptibility to infection and various immunologically mediated pathologies. Our laboratory has explored interdependence in the programming and development of the hypothalamo-pituitary-gonadal axis and thymus using experimental model of neonatal androgenization. We have outlined critical points in the complex process of T-cell development depending on neonatal androgen imprinting and the peripheral outcome of these changes and have pointed to underlying mechanisms. Our research has particularly contributed to an understanding of the putative role of changes in catecholamine-mediated communications in the thymopoietic alterations in adult neonatally androgenized rats.

References

Sep 1, 1976·Clinical Endocrinology·M G ForestJ Bertrand
Apr 1, 1977·The Journal of Pathology·E J Ruitenberg, J M Berkvens
May 1, 1991·Journal of Reproductive Immunology·P C HoJ W Lawton
Apr 1, 1988·The International Journal of Neuroscience·M DardenneJ F Bach
Dec 1, 1987·Immunology Letters·B D Janković
Sep 1, 1985·The Journal of Pediatrics·C A Sáenz de RodríguezL Conde de Borrego
Jan 1, 1973·International Archives of Allergy and Applied Immunology·K Isaković, B D Janković
Nov 15, 1972·Experientia·W Pierpaoli, E Sorkin
May 24, 1974·Nature·H O Besedovsky, E Sorkin
Feb 1, 1971·Irish Journal of Medical Science·N Clarke, M Collins
Jan 1, 1984·Annual Review of Neuroscience·A P Arnold, R A Gorski
Jan 1, 1984·Endocrine Reviews·C J Grossman
Jan 1, 1980·Journal of Immunopharmacology·E S RavecheA D Steinberg
Jan 1, 1995·International Review of Cytology·Y Ohta
Jul 1, 1995·Neuroendocrinology·T DanevaR C Gaillard
Nov 1, 1994·Immunology Today·J E Blalock
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Mar 1, 1995·Neuroimmunomodulation·G LeposavicD Kosec
Feb 1, 1996·Endocrine Reviews·H O Besedovsky, A del Rey
May 1, 1996·The Journal of Endocrinology·D R Mann, H M Fraser
May 1, 1996·Pharmacology, Biochemistry, and Behavior·G LeposavićD Kosec
Aug 1, 1996·Endocrine Reviews·N J Olsen, W J Kovacs
Jan 1, 1997·Annual Review of Immunology·T Tada
Jul 1, 1997·Experimental Gerontology·N FabrisM Provinciali
Oct 23, 1997·Journal of the National Cancer Institute·W B Ershler, D L Longo
Jan 27, 1998·Cellular and Molecular Neurobiology·D Becú-VillalobosC Libertun
Jun 18, 1998·Annals of the New York Academy of Sciences·J W Hadden
Sep 11, 1999·General and Comparative Endocrinology·N UotinenT Ylikomi

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Citations

Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan
Oct 4, 2017·Expert Review of Clinical Immunology·David N O'DriscollEleanor J Molloy

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