Role of granulosa cell mitogen-activated protein kinase 3/1 in gonadotropin-mediated meiotic resumption from diplotene arrest of mammalian oocytes

Growth Factors
Kankshi SahuShail K Chaube

Abstract

In mammals, preovulatory oocytes are encircled by several layers of granulosa cells (GCs) in follicular microenvironment. These follicular oocytes are arrested at diplotene arrest due to high level of cyclic nucleotides from encircling GCs. Pituitary gonadotropin acts at the level of encircling GCs and increases adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) and activates mitogen-activated protein kinase 3/1 (MAPK3/1) signaling pathway. The MAPK3/1 disrupts the gap junctions between encircling GCs and oocyte. The disruption of gap junctions interrupts the transfer of cyclic nucleotides to the oocyte that results a drop in intraoocyte cAMP level. A transient decrease in oocyte cAMP level triggers maturation promoting factor (MPF) destabilization. The destabilized MPF finally triggers meiotic resumption from diplotene arrest in follicular oocyte. Thus, MAPK3/1 from GCs origin plays important role in gonadotropin-mediated meiotic resumption from diplotene arrest in follicular oocyte of mammals.

References

Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C M Crews, R L Erikson
Apr 1, 1988·The Journal of Cell Biology·A Kazlauskas, J A Cooper
Mar 1, 1988·Molecular and Cellular Endocrinology·N DekelI Sherizly
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L B Ray, T W Sturgill
Apr 1, 1993·Molecular and Cellular Biology·J PosadaJ A Cooper
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·T ChoiG F Vande Woude
Jul 27, 1999·Zygote : the Biology of Gametes and Early Embryos·Q Y SunH Breitbart
Aug 23, 2000·Biology of Reproduction·K KikuchiY Toyoda
Nov 18, 2000·The EMBO Journal·M H VerlhacB Maro
Jan 6, 2001·Molecular Reproduction and Development·S M DownsM Hunzicker-Dunn
Feb 28, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·A TrounsonG Jones
Mar 30, 2001·The Journal of Biological Chemistry·Z Chen, M H Cobb
Jan 21, 2003·Biology of Reproduction·Satoshi OhashiHideaki Tojo
Mar 11, 2003·Zygote : the Biology of Gametes and Early Embryos·B Meinecke, C Krischek
Apr 20, 2004·Molecular Reproduction and Development·Marie Saint-DizierSylvie Chastant-Maillard
Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Lisa M Mehlmann
Feb 20, 2007·Biochimica Et Biophysica Acta·Menachem KatzYosef Yarden
Feb 24, 2007·Nature Reviews. Immunology·Yusen LiuLeif D Nelin
May 31, 2007·Molecular Endocrinology·Cheng-Guang LiangQing-Yuan Sun
Oct 25, 2007·Cell Cycle·Genaro Pimienta, Jaime Pascual
Mar 14, 2008·Biology of Reproduction·Sagit Sela-AbramovichNava Dekel
May 16, 2009·Molecular Human Reproduction·Meijia ZhangGuoliang Xia
Jun 23, 2010·Journal of Cellular Biochemistry·Ashutosh N PandeyShail K Chaube
Apr 27, 2012·Physiological Reviews·John M Kyriakis, Joseph Avruch

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.