Role of growth factors on extracellular matrix production by chick embryo fibroblasts in vitro. Antagonist effect of TGF-beta through the control of IL-1 and IL-1Ra secretion

M BodoE Becchetti


Growth factors and extracellular matrix (ECM) macromolecules create specific environments that regulate cell proliferation and differentiation during embryonic development. This study had two main aims: (1) to characterize the phenotype of 7- and 13-day-old chick embryo fibroblasts treated with interleukin 1 (IL-1) and interleukin 6 (IL-6) evaluating in particular the neosynthesis of the total proteins and of the fibronectin (FN); (2) to examine the mechanisms through which transforming growth factor beta (TGF-beta) antagonizes the action of IL-1. The results show that protein neosynthesis and secretion is modulated by treatment with IL-1 and IL-6 only in 7-day-old fibroblasts. IL-1 favours cellular accumulation, while IL-6 promotes secretion more. FN, isolated by affinity chromatography and analysed by SDS-PAGE and flurography, is produced in greater concentrations by 7-day-old fibroblasts. Treatment with IL-1 promotes the accumulation of FN in the cellular compartment both at 7 and 13 days, while it stimulates the secretion only in 7-day-old fibroblasts. IL-6 only has a stimulating effect on the processes of accumulation and secretion on 13-day-old fibroblasts. The authors show in addition, that TFG-beta blocks the IL-1 induc...Continue Reading


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Related Concepts

Chick Embryo
Extracellular Matrix
Protein Biosynthesis
Transforming Growth Factor beta

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