PMID: 8603030Jan 1, 1996Paper

Role of growth factors, steroid and peptide hormones in the regulation of human prostatic tumor growth

The Journal of Steroid Biochemistry and Molecular Biology
M MottaP Limonta

Abstract

Previous work carried out in the authors' laboratory has shown that LHRH agonists directly inhibit the proliferation of hormone-responsive and hormone-independent human prostatic cancer cell lines (respectively LNCaP and DU145). In addition, the hormone-dependent LNCaP cells respond to a challenge with testosterone with an increase in growth rate. The following experiments have been performed to investigate whether the LHRH agonists might act by interfering with the stimulatory actions of either the EGF/TGF alpha system or androgens. The results obtained in LNCaP and DU145 cells show that LHRH agonists counteract the mitogenic action of the EGF/TGF alpha system. This effect is mediated by a decrease in the concentration of EGF receptors. In addition, in the hormone-dependent LNCaP cells, the treatment with LHRH agonists antagonizes the proliferation promoting effect of testosterone, which in turn appears to be mediated by the activation of the locally expressed EGF/TGF alpha system. Finally, the results suggest the presence in LNCaP cells of a soluble peptidase able to degrade LHRH. In conclusion, the present data suggest an intimate interplay among the actions of LHRH agonists, of androgens and of growth factors, thus, support...Continue Reading

References

Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·K R StoneD F Paulson
Jul 1, 1992·The Journal of Clinical Endocrinology and Metabolism·P LimontaM Motta
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·B ZuckC Knabbe
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C L EatonK Griffiths
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C KnabbeK D Voigt
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·A L SchuurmansE Mulder
Jan 24, 1991·The New England Journal of Medicine·R F Gittes
Dec 20, 1990·The Journal of Steroid Biochemistry and Molecular Biology·A QayumJ Waxman
Dec 1, 1982·Analytical Biochemistry·H BergerB Mehlis
Oct 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·P Negri-Cesi, M Motta

❮ Previous
Next ❯

Citations

May 23, 2001·Molecular and Cellular Endocrinology·G SicaF Iacopino
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·G EmonsA V Schally
Nov 5, 2003·Reproductive Biology and Endocrinology : RB&E·Carsten Gründker, Günter Emons
Mar 21, 2006·Cancer Letters·Sarah KrausRony Seger
Jan 1, 2015·European Journal of Endocrinology·Santosh KumarPinaki Dutta
Jul 16, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Lívia L CorrêaMônica R Gadelha
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Lívia L CorrêaMônica R Gadelha
Dec 18, 2020·International Journal of Molecular Sciences·Fabrizio FontanaPatrizia Limonta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.