Role of growth hormone in regulating lipolysis, proteolysis, and hepatic glucose production during fasting.

The Journal of Clinical Endocrinology and Metabolism
Alla A SakharovaA L Barkan

Abstract

Fasting is associated with suppressed insulin and augmented GH secretion. The involvement of each mechanism in the regulation of fuel mobilization during fasting is unknown. To ascertain the role of GH in the regulation of the rates of lipolysis, proteolysis, and hepatic glucose production (HGP) during the physiological daily feed/fast cycle and after 2 d of complete fasting, we used a model of selective GH suppression by the administration of GHRH receptor antagonist (GHRH-A). We conducted an open label in-patient study in the General Clinical Research Center at the University of Michigan. Six healthy, nonobese volunteers participated. We assessed 24-h plasma GH concentration and rates of lipolysis, proteolysis, and HGP using stable isotope techniques after an overnight fast and after 2 d of fasting. GHRH-A suppressed plasma GH by about 65% during the fed state (P = 0.015) but did not alter the rates of lipolysis, proteolysis, or HGP. Fasting for 2 d suppressed plasma insulin concentration by about 80% and elevated plasma GH about 4-fold (both P < 0.01). This was accompanied by a doubling in the rate of lipolysis, an approximately 40% increase in proteolysis, and an approximately 30% decline in HGP (all P < 0.05). Preventing t...Continue Reading

References

Jan 1, 1991·Hormone Research·F SalomonP H Sönksen
Jun 3, 1989·Lancet·J O JørgensenJ S Christiansen
Oct 1, 1987·The American Journal of Clinical Nutrition·K S NairD E Matthews
Nov 1, 1982·The Journal of Clinical Endocrinology and Metabolism·P R Bratusch-MarrainR A DeFronzo
Jan 1, 1993·Hormone Research·P Mårin, P Björntorp
Apr 1, 1997·The Journal of Physiology·B StallknechtH Galbo
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Craig A JaffePaul B Watkins
Jun 12, 2003·American Journal of Physiology. Endocrinology and Metabolism·Helene NørrelundNiels Møller
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Jianjian ShiMorali D Sharma
Mar 31, 2005·American Journal of Physiology. Endocrinology and Metabolism·Matthew P HarberJeffrey F Horowitz
Jun 24, 2005·The Journal of Clinical Endocrinology and Metabolism·Matthew P HarberJeffrey F Horowitz

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Citations

Nov 23, 2011·European Journal of Applied Physiology·Daniel W D West, Stuart M Phillips
Mar 3, 2011·The Journal of Clinical Investigation·Brandon C SosEthan J Weiss
Oct 13, 2009·The Journal of Clinical Endocrinology and Metabolism·Louise MollerJens Otto Lunde Jorgensen
Feb 11, 2014·General and Comparative Endocrinology·Carlos G Martínez-MorenoMaricela Luna
Dec 24, 2013·The Journal of Endocrinology·Pouneh K Fazeli, Anne Klibanski
May 30, 2014·Nutrition Research Reviews·Gema FrühbeckAmaia Rodríguez
Mar 6, 2012·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B SalginJ Frystyk
Jan 10, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daniel E CrockerDaniel P Costa
Jul 22, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L Y Leung, Norman Y S Woo
Sep 24, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Niels MollerJens O Jorgensen
Apr 1, 2016·Medicinal Research Reviews·Wing Yan So, Po Sing Leung
Mar 20, 2014·General and Comparative Endocrinology·Maricela LunaCarlos Arámburo
May 6, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jose Cordoba-ChaconRhonda D Kineman
Mar 11, 2015·Endocrine·Roberto Salvatori
Mar 19, 2014·Journal of the Neurological Sciences·S T NgoP A McCombe
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Raffaella ComitatoFabio Virgili
May 4, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K W Ter HorstM J Serlie
Dec 24, 2018·Endocrine Reviews·Manuel H Aguiar-Oliveira, Andrzej Bartke
Feb 26, 2009·Endocrine Reviews·Niels Møller, Jens Otto Lunde Jørgensen
Feb 7, 2019·The Journal of Clinical Endocrinology and Metabolism·Esben Thyssen VestergaardJens Otto Lunde Jørgensen
Mar 13, 2019·The Journal of Clinical Endocrinology and Metabolism·Alécia A Oliveira-SantosManuel H Aguiar-Oliveira
Jun 14, 2014·The Journal of Clinical Endocrinology and Metabolism·Elenilde Gomes-SantosManuel H Aguiar-Oliveira
May 16, 2019·Molecular Nutrition & Food Research·Shraddha D RegeFernando Gomez-Pinilla
Aug 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Isadora C FurigoJose Donato
May 11, 2018·Journal of Molecular Endocrinology·Rhonda D KinemanAndré Sarmento-Cabral
Oct 1, 2019·Endocrine Journal·Takahiro SatoMasayasu Kojima
Sep 17, 2020·Reviews in Endocrine & Metabolic Disorders·Manuel H Aguiar-Oliveira, Roberto Salvatori
Jan 12, 2019·Science·Andrew WangRuslan Medzhitov
Dec 5, 2019·Frontiers in Neuroscience·Kassandra E CoupalVictoria E Claydon
Aug 17, 2019·Frontiers in Endocrinology·Greisa VilaGünter K Stalla
Jan 15, 2021·Cells·Jose DonatoRenata Frazão
Dec 30, 2020·Biomolecules·Antonella MuscellaSanto Marsigliante
Feb 16, 2021·Problemy e̊ndokrinologii·E L SorkinaA Barkan
May 1, 2021·Animals : an Open Access Journal From MDPI·Mousa ZarrinLorenzo E Hernández-Castellano

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