Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding

Pathologie-biologie
P D CaniR Burcelin

Abstract

A recent growing number of evidences shows that the increased prevalence of obesity and type 2 diabetes cannot be solely attributed to changes in the human genome, nutritional habits, or reduction of physical activity in our daily lives. Gut microflora may play an even more important role in maintaining human health. Recent data suggests that gut microbiota affects host nutritional metabolism with consequences on energy storage. Several mechanisms are proposed, linking events occurring in the colon and the regulation of energy metabolism. The present review discusses new findings that may explain how gut microbiota can be involved in the development of obesity and insulin resistance. Recently, studies have highlighted some key aspects of the mammalian host-gut microbial relationship. Gut microbiota could now be considered as a "microbial organ" localized within the host. Therefore, specific strategies aiming to regulate gut microbiota could be useful means to reduce the impact of high-fat feeding on the occurrence of metabolic diseases.

References

Nov 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R M ShortP Sharon
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E FerreroS M Goyert
Feb 16, 2000·The British Journal of Nutrition·H P KruseM Blaut
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anita C E VreugdenhilWim A Buurman
Jul 8, 2003·The Journal of the British Menopause Society·Christopher SmejkalAnne McCartney
Aug 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jian Xu, Jeffrey I Gordon
Dec 18, 2003·The Journal of Clinical Investigation·Stuart P WeisbergAnthony W Ferrante
May 27, 2004·World Journal of Gastroenterology : WJG·Zhong-Tang WangZhi-Yong Sheng
Jun 10, 2004·Digestive Diseases and Sciences·Elizabeth A GriffithsPearay L Ogra
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Mikio TomitaMasahiro Hayashi
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Nov 27, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chieko Mitaka
Mar 26, 2005·Science·Fredrik BäckhedJeffrey I Gordon
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Sep 24, 2005·Journal of Endotoxin Research·Richard L Kitchens, Patricia A Thompson
Dec 13, 2005·European Journal of Clinical Nutrition·P D CaniN M Delzenne
Jul 11, 2006·Advances in Applied Microbiology·S KolidaG R Gibson
Sep 13, 2006·The Journal of Trauma·Zhongtang WangZhiyong Sheng
Oct 21, 2006·The Journal of Clinical Investigation·Hang ShiJeffrey S Flier
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Feb 3, 2007·European Journal of Clinical Nutrition·S KolidaG R Gibson
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Jun 21, 2007·PLoS Biology·Jian XuJeffrey I Gordon
Sep 7, 2012·Diabetes, Obesity & Metabolism·S E KahnK M Utzschneider

❮ Previous
Next ❯

Citations

Oct 4, 2011·Acta Diabetologica·Rémy BurcelinJacques Amar
Oct 1, 2010·Internal and Emergency Medicine·Emidio ScarpelliniAntonio Gasbarrini
Oct 25, 2011·The British Journal of Nutrition·Sabine WagnerbergerIna Bergheim
Jan 10, 2013·The British Journal of Nutrition·Sanjoy GhoshDeanna L Gibson
May 1, 2013·Critical Reviews in Food Science and Nutrition·Jenni LappiKaisa Poutanen
Jun 19, 2013·Critical Reviews in Food Science and Nutrition·L TriguerosE Sendra
May 19, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Shengli Ding, Pauline K Lund
May 29, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claire Barbier de La SerreHelen E Raybould
Nov 26, 2011·Journal of Translational Medicine·Shaheen E Lakhan, Annette Kirchgessner
Oct 30, 2009·International Journal of Molecular Sciences·Huey-Shi LyeMin-Tze Liong
Jun 13, 2012·World Journal of Gastroenterology : WJG·Chourouk EttreikiPauline M Anton
Jul 20, 2012·International Journal of Biological Sciences·Omotayo O ErejuwaMohd S Ab Wahab
Jan 15, 2014·Diabetes Research and Clinical Practice·Juliana C N ChanJonathan Shaw
Mar 22, 2014·Clinical and Translational Gastroenterology·Haili WangRichard N Fedorak
Apr 14, 2015·Periodontology 2000·Alpdogan KantarciThomas E Van Dyke
May 25, 2012·Annales de cardiologie et d'angéiologie·V Blasco-BaqueR Burcelin
Jan 19, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Zhong-Wen WuLan-Juan Li
Sep 8, 2010·Current Opinion in Biotechnology·Vítor Martins dos SantosWillem M de Vos
May 8, 2009·Diabetes & Metabolism·M SerinoR Burcelin
Jul 8, 2008·International Journal of Pharmaceutics·Emma L McConnellAbdul W Basit
Mar 9, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S de KortA A M Masclee
May 3, 2012·Oral Diseases·C BenguiguiJ Amar
Aug 14, 2010·Gastroenterology Research and Practice·Gakuhei SonIan N Hines
Jun 2, 2015·Frontiers in Immunology·Karin de Punder, Leo Pruimboom
Sep 29, 2012·Gut Microbes·Eileen F MurphyPaul D Cotter
Dec 17, 2014·Obesity Surgery·Camila S CardinelliDan L Waitzberg
Oct 11, 2005·The Journal of Nutritional Biochemistry·Soon Ah KangYoongho Lim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.