Role of haptoglobin phenotype in end-stage kidney disease

Nephron. Experimental Nephrology
Zvi BurbeaAndrew P Levy

Abstract

We recently reported that haptoglobin (Hp) phenotype 1-1 is protective against the development of nephropathy in normal creatinine diabetics. In the present study, we sought to determine if Hp phenotype also plays a role in renal deterioration by determining Hp phenotypes in a consecutive series of patients with chronic renal failure (CRF) in hemodialysis (HD) and predialysis clinics. Three hundred and ninety-two patients on HD for less than 2 years and 182 predialysis patients (creatinine clearance time [CCT] <35 ml/min) were subjected to Hp phenotyping. Age, gender and presence of diabetes or hypertension were recorded. Patients were stratified according to age (above and below 60 years) and severity of renal dysfunction (CRF or HD). We observed a markedly lower prevalence of the Hp 1-1 phenotype in HD patients under 60 years of age compared to patients with CRF or compared to the general population. This was not due to differences in the threshold for dialysis initiation among patients with different Hp types or to decreased survival of patients with Hp 1-1 prior to entering HD. In HD patients 60 years and over, Hp 1-1 prevalence was increased, as observed with other diseases in this age group. The prevalence of Hp 1-1 is de...Continue Reading

Citations

Jun 24, 2011·Kidney International·Sundararaman Swaminathan, Sudhir V Shah
Sep 8, 2007·European Journal of Internal Medicine·Sahar S BessaEhab M M Ali
Feb 14, 2015·Aging Cell·Alexey A FushanVadim N Gladyshev
Sep 22, 2016·Antioxidants & Redox Signaling·Christian Brix Folsted AndersenSøren Kragh Moestrup
May 26, 2007·Nature Clinical Practice. Nephrology·Farid M NakhoulAndrew P Levy
Apr 27, 2005·Diabetes/metabolism Research and Reviews·Rachel Miller-LotanAndrew P Levy
Oct 27, 2004·Clinical Chemistry·Nina S Levy, Andrew P Levy
Sep 14, 2016·Clinical Diabetes : a Publication of the American Diabetes Association·Mark MacKellar, David J Vigerust

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