PMID: 3756137Jul 29, 1986Paper

Role of head group structure in the phase behavior of amino phospholipids. 1. Hydrated and dehydrated lamellar phases of saturated phosphatidylethanolamine analogues

Biochemistry
J R SilviusT J O'Leary

Abstract

Analogues of dimyristoylphosphatidylethanolamine (DMPE) have been prepared with head groups modified by N-alkylation, alkylation of carbon 2 of the ethanolamine group, or interposition of extra methylene segments between the phosphoryl and amino groups. The phases formed by these lipids in aqueous dispersions have been examined by high-sensitivity differential scanning calorimetry and Raman spectroscopy. All of the DMPE analogues examined, excepting N-methyl-DMPE but including N-ethyl-DMPE, form hydrated gel phases that are metastable with respect to a dehydrated "high-melting" solid phase that has been observed previously for DMPE itself. The properties and the conditions of formation of this high-melting phase are qualitatively distinct from those of the "subgel" phase, which is observed for dipalmitoylphosphatidylcholine and for some of the DMPE analogues examined in this study. The high-melting phases of different DMPE analogues all exhibit similarly tight packing of the acyl chains, which however do not pack according to a single type of subcell that can be universally and specifically associated with this phase. Increasing the size of the PE head group invariably decreases the melting temperature of the hydrated gel phase...Continue Reading

Citations

Mar 1, 1991·Chemistry and Physics of Lipids·M W TateS M Gruner
Mar 1, 1991·Chemistry and Physics of Lipids·J R Silvius
Jan 1, 1994·Chemistry and Physics of Lipids·R Koynova, M Caffrey
Aug 14, 1992·Biochimica Et Biophysica Acta·D C Litzinger, L Huang
Jan 19, 2012·The Journal of Physical Chemistry. B·Kwan Hon ChengPentti Somerharju
Feb 11, 2012·Molecular Biology of the Cell·Cedric H De SmetAnton I P M de Kroon
Feb 12, 1998·Biochimica Et Biophysica Acta·D A PinkM J Zuckermann
Mar 13, 2014·Advances in Colloid and Interface Science·Cristina StefaniuHelmuth Möhwald
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Nov 1, 1995·Biochimica Et Biophysica Acta·J SalgadoJ C Gómez-Fernández
Apr 4, 2017·Biochimica Et Biophysica Acta. Biomembranes·Hitoshi MatsukiShoji Kaneshina
Jul 14, 1987·Biochemistry·J R SilviusM Zuckermann
May 1, 1993·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·Z ZhangJ Silvius
Jun 1, 1995·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J TobochnikZ Zhang
Jun 10, 2019·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Amanda M BiedermanElizabeth L Crockett

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