Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use in bleeding peptic ulcers in Japan

Journal of Gastroenterology
Hibiki OotaniKazuma Fujimoto

Abstract

Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known major causes of peptic ulcers. This study aimed to characterize the features of bleeding peptic ulcers in Japan. This prospective study evaluated 116 patients revealed to have bleeding peptic ulcers from January 2000 to December 2002. Eighty-eight of the 116 patients (75.9%) had H. pylori infection. Seventy (60.3%) patients were positive for H. pylori with no history of NSAID use (group A), and 18 (15.5%) were positive for H. pylori with a history of NSAID use (group B). Among the H. pylori-negative patients, 15 (12.9%) were associated with NSAID use (group C). Thirteen (11.2%) patients had no H. pylori infection or history of NSAID use (group D). Among the 33 patients with a history of NSAID use, 11 were on-demand NSAID users and 14 took daily low-dose aspirin. The patients in groups B and C were significantly older that those in groups A and D, and they more frequently had coexisting diseases compared with group A. In group D, 11 patients had atrophic changes revealed by endoscopic examination, suggesting a past H. pylori infection, and these atrophic changes remained at the time of bleeding. Many of the patients in group D had seri...Continue Reading

References

Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·A Sonnenberg
Mar 18, 1983·Science·L M LichtenbergerB A Hills
Jul 1, 1996·Journal of Gastroenterology and Hepatology·G M ForbesB J Collins
Aug 26, 1998·Journal of Gastroenterology and Hepatology·H WakabayashiA Watanabe
Oct 15, 1998·The American Journal of Gastroenterology·W K LeungA F Cheng
Nov 26, 1998·Scandinavian Journal of Gastroenterology·A E HenrikssonT Wadström
Jul 27, 2000·European Journal of Gastroenterology & Hepatology·K NishikawaM Asaka
Jul 29, 2000·Journal of Clinical Gastroenterology·G MeucciR de Franchis

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Citations

Jul 5, 2007·Journal of Gastroenterology and Hepatology·Niki E TsesmeliDimitrios T Karamitsos
Jan 5, 2011·Journal of Gastroenterology and Hepatology·Nanae TsuruokaKazuma Fujimoto
Jul 29, 2011·Journal of Gastroenterology and Hepatology·Masaki MiyamotoNoriaki Manabe
Aug 21, 2009·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Ryo ShimodaKazuma Fujimoto
Jul 21, 2012·World Journal of Gastrointestinal Endoscopy·Haruka FujinamiToshiro Sugiyama
May 14, 2009·Journal of Gastroenterology·Masayuki NakayamaKazuma Fujimoto
Jun 1, 2008·Clinical Journal of Gastroenterology·Ryuichi Iwakiri, Kazuma Fujimoto
Jul 9, 2013·The American Journal of Medicine·Rebecca D ChasonDon C Rockey
Apr 17, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Francis Ka-Leung ChanKentaro Sugano
Jan 12, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anshu MahajanAndrew Y Wang
Sep 12, 2015·The Korean Journal of Internal Medicine·Chen-Shuan ChungYi-Chia Lee
May 28, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Daisuke YamaguchiRyuichi Iwakiri
Sep 6, 2013·The Tohoku Journal of Experimental Medicine·Toshimitsu IwabuchiTooru Shimosegawa
Jun 1, 2012·Current Therapeutic Research, Clinical and Experimental·Shino ShimuraYoshikazu Kinoshita
Feb 24, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Mitsuhiro FujishiroKazuma Fujimoto
Jul 22, 2016·Prilozi·Goran Begovic, Redzep Selmani
Jun 18, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Young Woon Chang
Dec 18, 2007·Internal Medicine·Kumiko YoshiharaKazuma Fujimoto
Jun 13, 2009·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Akihiro Kimura, Toshihiko Iwamoto
Oct 31, 2008·Journal of Digestive Diseases·Christoph Heinrich HoubenChung Kwong Yeung

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