PMID: 8964719Mar 1, 1996Paper

Role of hematocrit in the recruitment of pulmonary diffusing capacity: comparison of human and dog

Journal of Applied Physiology
E Y WuC C Hsia

Abstract

In dogs, maximal O2 uptake (VO2max) per kilogram of body weight is two- to threefold that in humans; the difference cannot be explained solely by differences in structural features between species. We compared the functional recruitment of pulmonary diffusing capacity (DLCO) during exercise in dogs with that in humans to determine whether pulmonary gas exchange is matched to VO2max or the size of the lungs and to define the potential role of exercise-induced polycythemia in producing the superior aerobic capacity of the dogs. We compared the relationships of DLCO, membrane diffusing capacity (DMCO), and pulmonary capillary blood volume (Vc) with respect to pulmonary blood flow (Qc) by a rebreathing method during steady-state exercise in adult male human subjects and in conditioned adult male foxhounds. The slopes and intercepts of the relationships of DLCO and DMCO to Qc are significantly greater in dogs than in humans; the slopes of the relationship of Vc to Qc are similar. In dogs diffusive pulmonary gas transport is matched to the higher VO2max. The enhanced recruitment of DLCO and DMCO in dogs during exercise could potentially be explained entirely by the exercise-induced polycythemia, which is seen in dogs but not in humans.

Citations

Jun 1, 1997·Journal of Applied Physiology·A S Popel
Dec 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Beat SchulerMax Gassmann
May 8, 1999·Journal of Applied Physiology·C C HsiaD Shah
Apr 8, 2006·Journal of Applied Physiology·D Merrill DaneRobert L Johnson
Sep 30, 2018·The Journal of Experimental Biology·Kang Nian YapTony D Williams
Nov 25, 2020·Annual Review of Animal Biosciences·Jay F Storz, Zachary A Cheviron
Aug 12, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kang Nian Yap, Yufeng Zhang

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