Role of hemodynamic changes in the increased cation excretion after acute unilateral nephrectomy in the anesthetized dog

The Journal of Clinical Investigation
M H Humphreys, J C Ayus

Abstract

Studies were carried out in anesthetized dogs to characterize the increase in cation excretion which occurs after acute unilateral nephrectomy (AUN). 60 min after AUN, cation excretion had increased from 31.5+/-2.7 to 66.3+/-12.0 mueq/min (P < 0.005) and fractional cation excretion had increased from 0.56+/-0.05 to 1.03+/-0.14% (P < 0.005), as the glomerular filtration rate was unchanged and renal blood flow fell. The increased cation excretion was accompanied by an increase in fractional phosphate excretion, no change in chloride excretion, and a fall in renin secretion. These alterations in renal function were associated with marked changes in systemic hemodynamics: cardiac output fell from 2.52+/-0.24 to 1.85+/-0.16 liters/min (P < 0.001), as diastolic pressure rose without an overall increase in mean arterial pressure, and heart rate fell. To assess the importance of these hemodynamic changes in the renal response, AUN in a separate group of dogs was accompanied by the simultaneous opening of a surgically created femoral artery-to-vein fistula at flow matching the blood flow to the removed kidney. When this was done, no alterations in systemic or renal hemodynamics were observed, and cation excretion did not differ from con...Continue Reading

References

Nov 30, 1976·European Journal of Clinical Investigation·J P Guignard, J H Dirks
Mar 1, 1972·European Journal of Pharmacology·I A ReidW F Ganong
Feb 1, 1974·Kidney International·D E PotterM A Holliday
Mar 1, 1953·The Journal of Clinical Investigation·F H EPSTEINM MCDOWELL

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Citations

Feb 1, 1993·The American Journal of the Medical Sciences·J P ValentinA Mimran
May 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A FriedlanderR L Horst
Oct 1, 1980·Prostaglandins and Medicine·D A Hartupee, W J Weidner
Feb 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael H Humphreys
Feb 1, 1997·Canadian Journal of Physiology and Pharmacology·J P Valentin
Nov 1, 1996·Renal Failure·D W MoskowitzE E Simon
Dec 18, 2013·Electrophoresis·Talukder Z JuberyPrashanta Dutta
Jan 1, 1991·Kidney International·M H HumphreysE Wiedemann

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