PMID: 9546413Apr 18, 1998Paper

Role of hepatitis E virus in sporadic cases of acute and fulminant hepatitis in an endemic area (Chad)

The American Journal of Tropical Medicine and Hygiene
P CoursagetR Roue

Abstract

Forty-one patients with acute or fulminant hepatitis and 86 control patients were entered into a study of sporadic, acute, and fulminant hepatitis in the N'Djamena area of Chad in 1993. Acute hepatitis B was diagnosed in nine (22%) patients and acute hepatitis E in 27 (66%) patients. No acute hepatitis A was observed and 10% of the patients had serologic markers of hepatitis C virus (HCV) infection. Dual acute hepatitis B and E were observed in four patients (10%) and acute HEV infection was associated with chronic hepatitis B surface antigen carriage in 16 (39%). Epidemiologic findings concerning HBV from Chad suggest that these patients had undiagnosed chronic liver disease due to HBV, with acute deterioration caused by superimposed HEV replication. Moreover, it is obvious that in developing countries only the most severe cases of hepatitis are seen in hospital settings and a large proportion of them are related to superinfection with HBV and HEV. Antibody to HEV was observed in 22% of the control patients. This observation and the fact that epidemic and sporadic cases of HEV are observed in Chad indicates that HEV is highly endemic in this country.

Citations

Jan 21, 2004·Journal of Gastroenterology and Hepatology·Jeyamani RamachandranGeorge M Chandy
Jan 21, 2004·Journal of Gastroenterology and Hepatology·Paul J GowPeter W Angus
Oct 18, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vikram BhatiaSubrat Kumar Acharya
Jan 5, 2012·World Journal of Hepatology·Eyasu H Teshale, Dale J Hu
Jan 8, 2014·Clinical Microbiology Reviews·Lisa J KrainAlain B Labrique
Jun 7, 2014·BMC Infectious Diseases·Jong-Hoon KimThomas F Wierzba
Nov 12, 2014·Hepatitis Monthly·Marten Schulz, Eckart Schott
Jul 20, 2004·World Journal of Gastroenterology : WJG·Yue-Bo YangLin Ma
Jul 5, 2005·Journal of Virology·Hélène van CuyckPierre Roques
Jul 30, 2005·World Journal of Gastroenterology : WJG·Xiao-Mao LiShui-Sheng Zhou
Apr 16, 2011·BMC Infectious Diseases·Alice I GoumbaNarcisse P Komas
May 7, 2013·World Journal of Hepatology·Tomoya KishiKazuma Fujimoto
Mar 14, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Xihui JiangChao Sun
Jul 6, 2004·Drugs·Harald Claus Worm, Gerhard Wirnsberger
Oct 9, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Steffie HeemelaarShonag B P Mackenzie

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