Role of hepatocellular regeneration in chlordecone potentiated hepatotoxicity of carbon tetrachloride.

Archives of Toxicology
P R KodavantiHarihara M Mehendale

Abstract

Previous histomorphometric studies led us to hypothesize that suppression of hepatocellular regeneration and the repair of the hepatolobular architecture was involved besides bioactivation phenomenon in the progressive and irreversible phase of toxicity resulting from CD + CCl4 interaction. We have recently observed significant protection from CD potentiated CCl4 toxicity in animals which are stimulated for active hepatocellular regeneration. The present work is an extension of our earlier histomorphometric investigation, taking 3H-thymidine (3H-T) incorporation as a biochemical parameter to assess hepatocellular regeneration followed by autoradiographic analysis of liver sections in normal (N) or chlordecone (CD) treated (10 ppm in diet for 15 days) male rats undergoing sham (SH) or partial hepatectomies (PH). Initial experiments established that in normal (N) rats, greatest 3H-T incorporation into hepatocellular nuclear DNA occurs at 2 days post-PH which returns to basal levels by 7 days. CD treatment alone did not change this phenomenon. 3H-T incorporation into nuclear DNA and the percentage of labelled cells as evidenced by autoradiography of liver sections were significantly elevated in N rats at 1-2 h after CCl4 (100 micr...Continue Reading

References

Feb 1, 1979·Toxicology and Applied Pharmacology·L R Curtis, H M Mehendale
Mar 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T NishihiraT Tobe
Apr 1, 1988·Toxicology and Applied Pharmacology·H M Mehendale, J S Klingensmith
Jul 1, 1970·Biochemical Pharmacology·P T Henderson, K J Kersten
Sep 28, 1967·The New England Journal of Medicine·N L Bucher
Apr 1, 1982·Toxicology Letters·J S Klingensmith, H M Mehendale
Aug 1, 1983·Experimental and Molecular Pathology·J S KlingensmithH M Mehendale
Jun 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·H M Mehendale
Aug 1, 1956·Experimental Cell Research·J CHAUVEAUC ROUILLER
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Dec 1, 1954·The Anatomical Record·J J JAFFE

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Citations

Jan 1, 1993·Archives of Toxicology·V C Rao, H M Mehendale
Jan 1, 1991·The International Journal of Biochemistry·M G Soni, H M Mehendale
Mar 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E J Calabrese, H M Mehendale
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H M Mehendale, S D Ray
Mar 1, 1995·Environmental Health Perspectives·R S MangipudyH M Mehendale
Jul 1, 1996·Environmental Health Perspectives·R S MangipudyH M Mehendale
May 1, 1994·Toxicologic Pathology·K N Thakore, H M Mehendale
Jun 1, 1994·Journal of Biochemical Toxicology·H M MehendaleC V Rao
Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R KodavantiH M Mehendale
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S ChandaH M Mehendale
Jan 1, 1991·Toxicologic Pathology·K N Thakore, H M Mehendale
Jan 1, 1991·Toxicologic Pathology·V C Rao, H M Mehendale
Mar 15, 1991·Toxicology and Applied Pharmacology·M G Soni, H M Mehendale

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