Role of high endothelial postcapillary venules and selected adhesion molecules in periodontal diseases: a review

Journal of Periodontal Research
Aldona KasprzakM Konkol

Abstract

Periodontitis is accompanied by the proliferation of small blood vessels in the gingival lamina propria. Specialized postcapillary venules, termed periodontal high endothelial-like venules, are also present, and demonstrate morphological and functional traits similar to those of high endothelial venules (HEVs) in lymphatic organs. The suggested role of HEVs in the pathogenesis of chronic periodontitis involves participation in leukocyte transendothelial migration and therefore proinflammatory effects appear. Recent observations suggest that chronic periodontitis is an independent risk factor for systemic vascular disease and may result in stimulation of the synthesis of acute phase protein by cytokines released by periodontal high endothelial cells (HECs). However, tissue expression of HEV-linked adhesion molecules has not been evaluated in the gingiva of patients with chronic periodontitis. This is significant in relation to potential therapy targeting expression of the adhesion molecules. In this review, current knowledge of HEV structure and the related expression of four surface adhesion molecules of HECs [CD34, platelet endothelial cell adhesion molecule 1, endoglin and intercellular adhesion molecule 1 (ICAM-1)], involved...Continue Reading

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Citations

Dec 20, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Fábio Ramôa PiresOslei Paes de Almeida
Apr 9, 2014·Scientific Reports·Kana SugawaraAkihiro Umezawa
Nov 20, 2013·Journal of Natural Products·Marcelo H NapimogaWaldiceu A Verri
Aug 21, 2014·Journal of Dental Research·R Marfil-ÁlvarezA Catena
Nov 11, 2017·Frontiers in Immunology·Ljubomir VitkovMatthias Hannig
Jan 19, 2019·Journal of Periodontal Research·Patrícia Guerra Peixe GonçalvesBruno Cesar de Vasconcelos Gurgel
Jul 18, 2019·Human Brain Mapping·Alona FysheTom M Mitchell
Jul 22, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei Fen Shih, Jong Yuh Cherng
Nov 12, 2014·International Journal of Molecular Medicine·Paulo José Lima JuizMario Julio Avila-Campos
Feb 4, 2019·Journal of Clinical Periodontology·Lewis WinningGerard J Linden
Nov 13, 2019·Oral Diseases·Isaac Suzart Gomes-FilhoFrank Scannapieco
Apr 5, 2020·Journal of Clinical Periodontology·Lewis WinningStefan Renvert
Aug 25, 2015·FEMS Yeast Research·Lindsay E O'DonnellGordon Ramage
Apr 18, 2015·Brazilian Oral Research·Zekeriya Taşdemir, Banu Arzu Alkan
Jul 10, 2020·Clinical Oral Investigations·Çiğdem Yılmaz ŞaştımBaşak Doğan

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