Role of high-fat diet on the effect of pioglitazone and melatonin in a rat model of breast cancer

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
B BojkováMarián Adamkov

Abstract

The risk of cancer may be modulated by drugs with pleiotropic effects and diet has been implicated in the efficacy of treatment. The oncopreventive effects of the antidiabetic drug pioglitazone (PIO) and the anti-insomnia drug melatonin (MT), in vivo, have been proven before, but using a standard-type diet. This study evaluated the impact of a high-fat diet on their efficacy in chemically induced mammary carcinogenesis in Sprague-Dawley rats. Mammary tumours were induced by N-methyl-N-nitrosourea (50 mg/kg, intraperitoneal, on the 41st postnatal day). PIO and MT administration was initiated 11 days before the carcinogen application and lasted until the termination of the experiment at 16 weeks. PIO was administered in a diet (10% fat) at a concentration of 100 ppm and MT was administered in tap water (20 mg/l). PIO, MT and the combination did not significantly alter the basic tumour growth parameters. However, histopathology showed a decrease in the high-grade/low-grade tumour ratio, particularly in animals that received combined treatment (P<0.01). Semiquantitative immunohistochemistry indicated the proapoptotic effect of chemoprevention, particularly in the drug combination group (P<0.01), but no changes in tumour cell prolif...Continue Reading

References

May 24, 1996·Life Sciences·S CosE J Sánchez-Barceló
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Jul 14, 1998·Molecular Cell·E MuellerB M Spiegelman
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·V G KaklamaniC S Mantzoros
Apr 25, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·V N AnisimovI Zusman
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R G Mehta
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·P TonioloA Zeleniuch-Jacquotte
Dec 21, 2000·Trends in Pharmacological Sciences·G J Murphy, J C Holder
Jan 10, 2001·Journal of Mammary Gland Biology and Neoplasia·J Russo, I H Russo
Jul 21, 2001·Journal of Molecular Endocrinology·L FajasJ Auwerx
Aug 29, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·C E ClayF H Chilton
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology· VijayalaxmiTerence S Herman
Jun 5, 2003·Breast Cancer Research and Treatment·H LiuE Elstner
Jun 7, 2003·Endocrine-related Cancer·E J Sánchez-BarcelóM D Mediavilla
Aug 23, 2003·Journal of Pineal Research·Mercedes M Leon-BlancoDavid Pozo
Jan 2, 2004·Breast Cancer Research and Treatment·Lisa RydénGöran Landberg
Jul 3, 2004·The Lancet Oncology·Christian GrommesMichael T Heneka
Jan 11, 2005·Nuclear Medicine Communications·Jean-Christophe PhilipsChristoph A Meier
Jan 15, 2005·Sleep Medicine Reviews·Bruno ClaustratGuy Chazot
Jan 4, 2006·Critical Reviews in Oncology/hematology·Tingting WangZhong Chao Han
Apr 15, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paola CostelliFilippo Rossi Fanelli
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir N AnisimovIrina A Vinogradova
Mar 9, 2007·Blood Cells, Molecules & Diseases·Zaher K OtrockAli I Shamseddine
Mar 22, 2007·Journal of the National Cancer Institute·Anne C M ThiébautArthur Schatzkin
Apr 3, 2007·International Journal of Cancer. Journal International Du Cancer·Susanna C LarssonAlicja Wolk
Jun 21, 2007·Molecular Cancer Research : MCR·Fu-Sheng ChouJoseph J Pinzone
May 17, 2008·PPAR Research·Yumiko YasuiTakuji Tanaka
Apr 22, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Hilal KocdorGul Guner
May 7, 2009·Cancer Biology & Therapy·Jose J MansureWassim Kassouf
Jun 29, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Bianka BojkováIvan Ahlers

❮ Previous
Next ❯

Citations

Nov 18, 2018·Endocrine-related Cancer·Priscilla A Furth
Dec 20, 2018·International Journal of Molecular Sciences·Bianka BojkováKarol Kajo
May 2, 2018·Current Medicinal Chemistry·Geir BjorklundSalvatore Chirumbolo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.