Role of high glycogen in underperfused diabetic rat hearts with added norepinephrine

Journal of Cardiovascular Pharmacology
M HiguchiM Sakanashi

Abstract

The relationship between cardiac dysfunction and glycogen level and/or duration of diabetes was examined during underperfusion (2 ml/min/g heart weight) with 10(-6)M norepinephrine (NE) in isolated 1- and 6-week streptozotocin-diabetic rat (diabetes mellitus, DM) hearts and non-DM hearts. Glycogen levels in non-DM and 1- and 6-week DM hearts were 85, 120, and 206 mumol/g dry weight, respectively, in the subendocardium. About 13 min after the start of underperfusion with NE, the diastolic tension in 1-week DM hearts began to increase when the glycogen level had decreased to half; in 6-week DM hearts, glycogen decreased more markedly without greater lactate accumulation, but these glycogen levels were still higher (104 mumol/g dry weight) than those in 1-week DM hearts and the diastolic tension did not increase. About 17 min after the onset of underperfusion, the glycogen decreased to the 13-min level of 1-week DM hearts (64 mumol/g dry weight) and the diastolic tension began to increase. Until 20 min after the onset of underperfusion, the injury was less in 6-week than in 1-week DM hearts. However, after 60-min underperfusion with NE, when the glycogen level was markedly low in both groups ( < 20 mumol/g dry weight), diastolic t...Continue Reading

Citations

Sep 4, 2014·The Journal of Physiological Sciences : JPS·M DervisevikB Miova
Jun 6, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ding An, Brian Rodrigues
Aug 5, 1998·The American Journal of Physiology·R RamasamyS Schaefer

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