Abstract
High-mobility group box-1 (HMGB1) acts as a proinflammatory cytokine that triggers and amplifies the inflammation cascade following ischemia/reperfusion (I/R). Ethyl pyruvate (EP) has been reported to inhibit HMGB1 release in several I/R models. This study was designed to investigate the potential role of HMGB1 in a rat myocardial I/R model and to determine the effect of EP. Male Sprague Dawley rats were subjected to 30 min myocardial ischemia and 48 h reperfusion. In protocol 1, the rats were assigned to one of four groups (n=16 per group): Phosphate-buffered saline (PBS) or recombinant human HMGB1 (rhHMGB1) at three different doses (1, 10 or 100 μg/kg). In protocol 2, the rats were also assigned to one of four groups (n=16 per group): Sham, control, EP and EP + rhHMGB1. EP (40 mg/kg) or rhHMGB1 (100 μg/kg) was injected intravenously prior to reperfusion. Hemodynamic measurements were performed, and myocardial infarct size (IS) was calculated. Western blotting was conducted to evaluate HMGB1, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expression levels. In the protocol 1 rats, the IS was markedly increased in the rhHMGB1 (100 μg/kg) group compared with that in the PBS group, and this increase was accompanied by e...Continue Reading
References
Apr 16, 1999·Circulation Research·R M FryerG J Gross
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Runkuan YangMitchell P Fink
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Sep 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Luis UlloaKevin J Tracey
Nov 12, 2003·Cytokine·Kevin A O'ConnorLinda R Watkins
Apr 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Y Joseph WooTodd Grand
Jan 25, 2005·Transplantation·Allan TsungDavid A Geller
Mar 30, 2005·The Journal of Experimental Medicine·Allan TsungTimothy R Billiar
Sep 6, 2005·Stroke; a Journal of Cerebral Circulation·Young-Mi YuJa-Kyeong Lee
Sep 19, 2006·Journal of Leukocyte Biology·Ari RouhiainenHeikki Rauvala
Feb 20, 2007·Cardiovascular Research·Maurits T DirksenDirk J G M Duncker
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Apr 24, 2008·Molecular Medicine·John R KluneAllan Tsung
Jun 20, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jialong GuoShunqing Zuo
Jun 25, 2008·Circulation·Martin AndrassyAngelika Bierhaus
Sep 11, 2008·Cardiovascular & Hematological Disorders Drug Targets·Ming Zhang, Li Chen
Sep 16, 2008·Transplantation Proceedings·K-Y ChungY S Kim
May 7, 2009·Anesthesiology·Qiang WangLize Xiong
Jul 5, 2012·American Journal of Physiology. Renal Physiology·May M RabadiBrian B Ratliff
Jun 4, 2013·Gene·Hua-Sheng DingQin-Qin Yu
Jan 24, 2014·Mediators of Inflammation·Miao ShenChuanyong Guo
Apr 29, 2014·International Journal of Cardiology·Xiaorong HuHong Jiang
Citations
Apr 2, 2015·International Journal of Cardiology·Zhaowei ZhuShenghua Zhou
Apr 8, 2015·International Journal of Cardiology·Rui-Jie GaoHeng-Chen Yao
Sep 1, 2015·Journal of Pharmacological Sciences·Li YaoXiaohua Wang
Jun 2, 2016·BMC Cardiovascular Disorders·Xing-Han TianMeng Chen
Nov 6, 2015·PloS One·Jincai HouJianxun Liu
Oct 1, 2018·Journal of Cellular Biochemistry·Quan-Fang ChenXiang-Tao Zeng
Feb 21, 2019·Journal of Cellular and Molecular Medicine·Jiyang XueQifeng Zhao
Dec 24, 2015·Journal of Cardiovascular Pharmacology·Hunan XiaoQian Yu
Dec 17, 2016·Journal of Inflammation·Runkuan YangTor Inge Tonnessen
Jan 10, 2020·Journal of Anesthesia·Takashige YamadaYoshifumi Kotake
Oct 27, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yan Fei QiMohan K Raizada
Jan 21, 2017·Experimental and Therapeutic Medicine·Jian-Zhe LiYang Yang
Jul 20, 2016·International Journal of Molecular Medicine·Xin GuoHua-Sheng Ding
Dec 2, 2015·Experimental and Therapeutic Medicine·Ren Rong, Xiao Xijun
Jan 28, 2021·PloS One·Jin Ho BeomJe Sung You
Apr 18, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Abdul WahidXiaohong Tang
Dec 12, 2018·Pharmacology & Therapeutics·Laura PellegriniFederica Limana
Jul 25, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chenxi LuQiang Wang
Jun 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Baoqing ChenYou Lu
Oct 6, 2021·Mycopathologia·JiaoJiao WangHang Sun
Nov 20, 2016·Current Opinion in Organ Transplantation·Hsi-Min HsiaoDaniel Kreisel
Jun 11, 2018·International Journal of Cardiology·Qi LiJun Yang