PMID: 9160895Apr 1, 1997Paper

Role of high molecular weight extracellular matrix proteins in glioma cell migration

Neuropathology and Applied Neurobiology
Rupavathana MahesparanRolf Bjerkvig

Abstract

Malignant human gliomas are characterized by an uncontrolled cell proliferation and infiltrative growth within the brain. Complete surgical removal is difficult due to disseminated tumour cells, and the fundamental mechanisms responsible for this spread are poorly understood. An extensive tumour cell movement along blood vessels is frequently observed and this may be due to specific interactions between tumour cell surface receptors and specific extracellular matrix (ECM) components present in conjunction with vascular elements. In order to investigate the influence of ECM on glioma cell migration, three different human glioma cell lines (U-373 MG, A-172 MG and HF-66) were exposed to known ECM components of the basement membrane (laminin, fibronectin and collagen type IV). Cell migration from multicellular spheroids was studied, using a custom-made medium which was prepared by removing the high molecular weight protein fraction (>100 kDa) from newborn calf serum by ultrafiltration. To this medium, the specific ECM components were added. For two of the cell lines (A-172 MG and U-373 MG), laminin was the most potent stimulator of glioma cell migration; the effect of laminin exceeded that evoked by ordinary serum-supplemented medi...Continue Reading

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Citations

Aug 23, 2005·BMC Cell Biology·Claudia Beatriz Nedel Mendes de AguiarAndréa Gonçalves Trentin
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·M E Berens, A Giese
Dec 23, 2015·Neural Regeneration Research·Rafet ÖzayYusuf Şükrü Çağlar
Jun 21, 2007·Cancer Cell International·Kimi HonmaTakahiro Ochiya
Feb 8, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Agnieszka Wanda Piastowska-CiesielskaTomasz Ochędalski
Sep 25, 2007·Journal of Neurosurgery·Yuji FukushimaKazuyuki Itoh
Oct 24, 2007·International Journal of Cancer. Journal International Du Cancer·Jian WangPer Ø Enger
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B B TysnesR Bjerkvig

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