Role of histamine and calcitonin gene-related peptide in the hyperemic response to hypertonic saline and H+ back-diffusion in the gastric mucosa of cats

Scandinavian Journal of Gastroenterology
H GislasonK Svanes

Abstract

The present study was undertaken to measure the output of histamine and calcitonin gene-related peptide (CGRP) from injured and restituting gastric mucosa into venous blood and to study the effect of acid back-diffusion on the release of these mediators and their role in the hyperemic response to injury. Stomachs of cats were perfused with saline at pH 1.0 or 7.4. Gastric mucosal blood flow (GMBF) was determined with radioactive microspheres, and blood flow in the portal vein and celiac artery was determined by transit-time flowmetry. H+ back-diffusion/secretion was measured by pH-stat titration and by measuring the arteriovenous base excess difference. Mucosal injury was produced by exposure to 2 M NaCl. Histamine and CGRP in portal venous blood were measured by radioimmunoassay. During mucosal exposure to 2 M NaCl GMBF increased, and histamine (0.23 nmol/min) and CGRP (1.2 pmol/min) were released from the mucosa into blood. The hyperemic response was reduced by pretreatment with H1 and H2 blockers and still further by addition of the blocker CGRP8-37. After mucosal damage and luminal perfusion at pH 7.4, GMBF and output of CGRP and histamine decreased towards base-line levels within 30 min. During luminal perfusion at pH 1.0 ...Continue Reading

References

May 1, 1977·Journal of Medicinal Chemistry·L J Schaad, B A Hess
May 1, 1976·The Journal of Physiology·I H Main, B J Whittle
Jan 1, 1991·Advances in Experimental Medicine and Biology·F SundlerR Håkanson
Mar 1, 1991·The American Review of Respiratory Disease·J BienenstockM H Perdue
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·H L WaldumB Schulze Søgnen
Jan 1, 1986·The British Journal of Dermatology·W Piotrowski, J C Foreman
Oct 1, 1988·The Journal of Allergy and Clinical Immunology·A M Morel, M A Delaage
Sep 1, 1989·Gastroenterology·R H SteadJ Bienenstock
May 1, 1980·Microvascular Research·P H GuthE Smith
Apr 1, 1993·Scandinavian Journal of Gastroenterology·H GislasonK Svanes

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Citations

Oct 12, 2001·Journal of Physiology, Paris·O M Abdel-SalamG Mózsik
May 1, 1997·Journal of Physiology, Paris·O M Abdel-SalamG Mózsik
Apr 18, 1998·Gastroenterology·P Holzer
Apr 20, 2006·Critical Reviews in Food Science and Nutrition·M N Satyanarayana
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A RydningJ E Grønbech

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