Role of histone deacetylase on nonalcoholic fatty liver disease.

Expert Review of Gastroenterology & Hepatology
Shifeng FuDengliang Liu

Abstract

Introduction: Nonalcoholic fatty liver disease (NAFLD) is a group of diseases related to metabolic abnormalities, which severely impairs the life and health of patients, and brings great pressure to the society and medical resources. Currently, there is no specific treatment. Histone deacetylases (HDACs) have recently been reported to be involved in the pathogenesis of NAFLD and are considered as new targets for the treatment of NAFLD.Area covered: In this review, we summarized the role of HDACs in the pathogenesis of NAFLD and proposed possible therapeutic targets in order to provide new strategies for the treatment of NAFLD.Expert commentary: HDACs and related signal pathways are widely involved in the pathogenesis of NAFLD and have the potential to become therapeutic targets. However, based on current research alone, HDACs cannot be practical applied to the treatment of NAFLD. Therefore, more research on the pathogenesis of NAFLD and the mechanism of HDACs is what we need most now.

References

Jul 7, 1969·Biochemical and Biophysical Research Communications·A Inoue, D Fujimoto
Jul 28, 1995·The Journal of Biological Chemistry·M Garcia-RamirezJ Ausio
Aug 27, 2003·Nature·Konrad T HowitzDavid A Sinclair
Aug 13, 1955·Nature·J H TAYLOR, W S GORDON
Oct 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alessandro VanniniStefania Di Marco
May 3, 2005·The Journal of Clinical Investigation·Kerry L DonnellyElizabeth J Parks
Feb 8, 2006·DNA and Cell Biology·Maryse BerthiaumeLuc Gaudreau
Apr 11, 2006·Nuclear Receptor Signaling·Megan A Maxwell, George E O Muscat
Oct 31, 2006·Nature Cell Biology·Jong In YookStephen J Weiss
Oct 24, 2007·Metabolism: Clinical and Experimental·Akiko ShimizuShuichi Kaneko
Nov 23, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Takashi KojimaNorimasa Sawada
Oct 3, 2008·The Journal of Clinical Investigation·Rusty L MontgomeryEric N Olson
May 28, 2009·Science Signaling·Roy L Silverstein, Maria Febbraio
May 30, 2009·Journal of Gastroenterology and Hepatology·Anuradha S DassanayakeH Janaka de Silva
Mar 12, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kausik DasAbhijit Chowdhury
Apr 29, 2010·Metabolism: Clinical and Experimental·Satish C KalhanMike Milburn
Jul 16, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Yue Zhao, Dennis Bruemmer
Nov 4, 2010·The Biochemical Journal·Agnieszka A KendrickKaren R Jonscher
Jan 18, 2011·Nature Structural & Molecular Biology·Jasmeen OberoiJohn W R Schwabe
Feb 16, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yu LiMengwei Zang
Aug 23, 2011·PloS One·Lydia W S FinleyMarcia C Haigis
Jul 20, 2012·Physiological Reviews·Ruben NogueirasMatthias H Tschöp
Jan 25, 2013·BMC Dermatology·Adrian J McNairnGéraldine Guasch
Apr 4, 2013·Nutrition Journal·Sylene Coutinho Rampche de CarvalhoLeila Maria M Beltrão Pereira

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