Role of HLA Adaptation in HIV Evolution

Frontiers in Immunology
Henrik KløverprisPhilip Goulder

Abstract

Killing of HIV-infected cells by CD8(+) T-cells imposes strong selection pressure on the virus toward escape. The HLA class I molecules that are successful in mediating some degree of control over the virus are those that tend to present epitopes in conserved regions of the proteome, such as in p24 Gag, in which escape also comes at a significant cost to viral replicative capacity (VRC). In some instances, compensatory mutations can fully correct for the fitness cost of such an escape variant; in others, correction is only partial. The consequences of these events within the HIV-infected host, and at the population level following transmission of escape variants, are discussed. The accumulation of escape mutants in populations over the course of the epidemic already shows instances of protective HLA molecules losing their impact, and in certain cases, a modest decline in HIV virulence in association with population-level increase in mutants that reduce VRC.

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Citations

Sep 10, 2016·Retrovirology·M-H TsaiP J R Goulder
Jul 6, 2019·Molecular Biology and Evolution·Fanny WegnerJudith Breuer
Aug 4, 2019·Journal of Virology·Thomas van Stigt ThansAngelique Hölzemer
Apr 24, 2020·Journal of Virology·Ming-Han Chloe TsaiPhilip Goulder
Mar 11, 2020·Frontiers in Immunology·Kyle SaylorChenming Zhang
Jul 28, 2020·BMC Infectious Diseases·Samara Tatielle Monteiro GomesAntonio Carlos Rosário Vallinoto
Aug 1, 2018·Frontiers in Immunology·Sheila F LumleyPhilippa C Matthews
Aug 29, 2019·Cells·Takashi Shiina, Antoine Blancher
Mar 7, 2019·Microorganisms·Yiding Yang, Vitaly V Ganusov
Jun 3, 2021·International Journal of Molecular Sciences·Ana Santos-PereiraNuno S Osório

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