Role of HMGB1 in regulation of STAT3 expression in CD4(+) T cells from patients with aGVHD after allogeneic hematopoietic stem cell transplantation

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Ya-Jing XuFang-Ping Chen

Abstract

Treg/Th17 balance plays a critical role in maintaining immune homeostasis of acute graft-versus-host disease (aGVHD) patients. STAT3 is an important factor involved in the instability of Treg and the promotion of Th17. HMGB1 is a cytokine mediator of inflammation and an important chromatin protein regulating gene transcription. In this study, we found that the expressions of HMGB1 and STAT3 were higher in CD4(+) T cells of patients with aGVHD compared with those without aGVHD, and the HMGB1 expression was positively correlated with the STAT3 expression. Simultaneously, their expressions were positively correlated with the severity of the aGVHD. We also demonstrated that HMGB1 could regulate the expression of STAT3 by modulation of its DNA methylation in CD4(+) T cells, moreover downregulated HMGB1 in aGVHD CD4(+) T cells could change the ratio of Treg/Th17. These data strongly suggest that HMGB1 plays a crucial role in the regulation of Treg/Th17 and progression of aGVHD.

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Citations

Feb 24, 2016·Human Immunology·Petya Apostolova, Robert Zeiser
Mar 24, 2020·Journal of Leukocyte Biology·Fernando AlvarezCiriaco A Piccirillo
Jul 16, 2020·Cells·Bernardo L RapoportRonald Anderson
Jan 11, 2019·Frontiers in Immunology·Sandeep KumarXuefang Cao
Jul 15, 2020·Journal of Hematology & Oncology·Shunling YuanJi Zhang
Jun 17, 2018·Science Immunology·Stefanie Frey-JakobsBodo Grimbacher
May 1, 2020·Chinese Journal of Integrative Medicine·Xiao-Long WuRui-Lan Gao
Sep 11, 2021·Journal of Translational Medicine·Jianyuan PanYongqin Tang

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