Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors

Human Pathology
Anne-Laure Rougemont, Jean-Christophe Tille

Abstract

Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking. Preliminary data from the literature suggest that HNF1β may represent a sensitive marker of YST. The specificity of HNF1β has not been addressed in GCT. A cohort of 49 YST specimens from 45 patients was designed, occurring either as pure tumors, or as a component of a mixed GCT. Immunohistochemistry was conducted on whole tumor sections using HNF1β. SALL4, OCT4, CD30, CDX2, Cytokeratin 19, Glypican 3, and GATA3 were used for classification of the GCT components. Patients were mostly male (39/45), aged 14 months to 49 years, with primary testicular tumors (37/39), or primary mediastinal pure YSTs (2/39). All 6 primary tumors occurring in females (6/45) were pure ovarian YSTs; age range was 4 to 72 years. HNF1β nuclear reactivity was seen in the YST component in all 49 tumors, with a moderate to strong nuclear pattern of staining. Embryonal carcinoma (EC, 0/32) and seminoma (0/6) were negative. Choriocarcinoma (6/6) showed faint focal cytoplasmic reactivity to HNF1β but no nuclear staining. In teratomas, only enteric-type glands showed nuclear reacti...Continue Reading

Citations

Jun 21, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alessandra GalloPeter Karl Bode
Jun 4, 2020·Pathology Oncology Research : POR·Michaela BártůPavel Dundr
May 25, 2021·Advances in Anatomic Pathology·Ziad M El-Zaatari, Jae Y Ro

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