Role of Hormone Therapy After Primary Surgery for Endometrioma: A Multicenter Retrospective Cohort Study

Reproductive Sciences
Seok Ju SeongEun-Ju Lee

Abstract

Endometriosis is a major cause of disability in women, and 40% to 50% of patients experience disease recurrence by 5 years after surgery. This multicenter retrospective cohort study (N = 588) determined the rate and risk factors for recurrent endometrioma after primary surgery and examined the role of postoperative hormone therapy. When recurrence was defined by sonographic identification of the endometrioma (≥20 mm in size), 61 (10.4%) patients experienced disease recurrence. The cumulative recurrence rates at 1, 2, 3, and 5 years after surgery were 2.2%, 4.9%, 6.9%, and 9.8%, respectively. To determine the risk factors for recurrence, the clinical factors of patients with and without recurrence were compared. There was a significantly increased risk of recurrence with posterior cul-de-sac (PCDS) obliteration (P = .031) and higher serum cancer antigen 125 (CA125) level (P = .005). A longer postoperative hormonal therapy duration (P < .01), absence of PCDS obliteration (P = .036), and lower serum CA125 level (P = .014) were associated with longer recurrence-free interval on multivariate analysis using the Cox regression model. Postoperative hormone therapy prolonged the interval from the time of surgery to the first recurrence....Continue Reading

References

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Citations

Feb 15, 2018·Reproductive Sciences·Maria Rosa Maduro
Mar 8, 2019·World Journal of Clinical Cases·Jun Woo BongJin Cheon Kim

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Methods Mentioned

BETA
hysterectomy

Software Mentioned

SPSS

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