PMID: 698952Nov 1, 1978Paper

Role of hormones in mammary neoplasia

Cancer Research
S Nandi

Abstract

A testable hypothesis for the role of hormones in mammary carcinogenesis with implications for other endocrine-related carcinogenesis is presented. The hypothesis is based on these observations: (a) hormones are involved, directly or indirectly, in regulating cell division in normal mammary cells: (b) emergence of overt mammary tumors requires hormonal stimulation of cells receiving carcinogenic stimulus; (c) normal mammary cells are of finite divisional capabilities, whereas neoplastic cells appear to have infinite divisional life; and (d) normal cells, when present in large quantities relative to the neoplastic cells, inhibit the growth of the latter cells. According to the hypothesis hormones play at least two roles in mammary carcinogenesis induced by diverse agents, such as viruses, chemicals, and radiation. First, hormones are necessary for DNA synthesis and mitosis of initial transformed cells for their conversion into fixed transformed cells with heritable characteristics. Second, hormones, by increasing the rate of cell division, shorten the reproductive life span of normal cells, eventually causing a reduction in the normal to transformed cell ratio in the population--a condition that allows the emergence of tumor cel...Continue Reading

Related Concepts

Mammary Neoplasms, Human
Tumor Promoters
Cell Division Phases
Cocarcinogenesis
Hormones
Mammary Neoplasms, Experimental
Neoplasm Transplantation
Oncogenic Viruses
Transplantation, Homologous

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