PMID: 6113604Jan 1, 1980Paper

Role of hormones in the mechanism of the swift increase in alcohol metabolism in the rat

Pharmacology, Biochemistry, and Behavior
T YukiR G Thurman

Abstract

Gastric intubation of female Sprague-Dawley rats (80--150 g) with one large dose (5 g/kg) of ethanol doubled both hepatic oxygen uptake and ethanol metabolism within 2.5 hr in the perfused rat liver (Swift Increase in Alcohol Metabolism--SIAM). Hepatic oxygen uptake could also be elevated by direct infusion of epinephrine and glucagon into the perfused liver. Alcohol treatment produced significant increases in circulating epinephrine, norepinephrine and glucose but did not effect levels of plasma immunoreactive insulin. Administration of alpha- and beta-adrenergic blocking agents, adrenalectomy and hypophysectomy prevented the increase in oxygen uptake due to ethanol treatment. These data suggest that catecholamines and possibly other hormones play an important role in the mechanism of the Swift Increase in Alcohol Metabolism (SIAM).

Citations

Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R G ThurmanE Glassman
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·S JiR G Thurman
Jan 1, 1981·Pharmacology & Therapeutics·E Mezey
Mar 8, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claudia von MontfortGavin E Arteel
Sep 8, 2015·Experimental and Molecular Pathology·Manuela G NeumanSamuel W French
Mar 12, 2015·Experimental and Molecular Pathology·S W French
Aug 25, 2007·Journal of Gastroenterology and Hepatology·Blair U Bradford
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OshitaS Kawano
Jan 1, 1985·Alcoholism, Clinical and Experimental Research·H TsukamotoC Largman
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·D M GilliamA C Collins
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·Samuel W French
Apr 1, 1988·Alcoholism, Clinical and Experimental Research·H SpeiskyK O Lindros
Aug 17, 2017·Biomolecules·Lauren G PooleGavin E Arteel
Jan 1, 1989·Journal of Toxicology. Clinical Toxicology·G E MinionL Boutiette

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Alcoholism, Clinical and Experimental Research
R G ThurmanE Glassman
Alcoholism, Clinical and Experimental Research
I R BravoV Gallardo
© 2021 Meta ULC. All rights reserved