Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy.

Journal of Neurovirology
Sarah GheuensI J Koralnik

Abstract

Because human leukocyte antigen (HLA) associations with various infectious diseases have recently been reported, we examined the role of HLA class I alleles in the development of progressive multifocal leukoencephalopathy (PML) or its outcome in 152 patients, including 123 Caucasians and 29 African Americans. Compared to a human immunodeficiency virus positive (HIV+) control population, we observed decreased frequency of HLA-A3 (P = 0.03) in the Caucasian PML group, whereas B18 (P = 0.02), was more frequent. No such difference was found among African American PML patients. We then sought to characterize differences in HLA between PML progressors, whose survival doesn't exceed 1 year, and survivors. Caucasian survivors were less likely to harbor A68 (P = 0.01), whereas African American survivors less frequently displayed Cw4 (P = .01). However, none of these differences reached statistical significance after Bonferroni correction for multiple testing. Further investigations are needed to assess the role of genetics in the incidence of PML or its outcome. Physicians may exercise caution in the use of immunomodulatory medications in patients whose genetic background is associated with an increased risk of PML.

References

Nov 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A V HillM Plebanski
Apr 20, 1995·The New England Journal of Medicine·M R ThurszA V Hill
Mar 12, 1999·Science·M CarringtonS J O'Brien
Jun 2, 2001·The New England Journal of Medicine·X GaoM Carrington
Dec 6, 2001·Nature Reviews. Genetics·G S Cooke, A V Hill
Apr 23, 2002·Journal of Virology·Chloe L ThioDavid L Thomas
Jan 15, 2003·Annual Review of Medicine·Mary Carrington, Stephen J O'Brien
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Susan M McKiernanDermot Kelleher
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Daniel L BohlDaniel C Brennan
Nov 1, 2006·Current Pharmaceutical Design·Brigitte Müller-Hilke, N Avrion Mitchison
Oct 3, 2007·The Journal of Clinical Investigation·Karen A McAulayDorothy H Crawford
Dec 3, 2008·Pediatrics·Luan-Yin ChangLin-Min Huang
Nov 11, 2009·Neurology·A MarzocchettiI J Koralnik

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Citations

Oct 25, 2012·Annual Review of Pathology·Sarah GheuensIgor J Koralnik
Jun 21, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hans H HirschCeline Leboeuf

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