Role of human milk in extremely low birth weight infants' risk of necrotizing enterocolitis or death.

Journal of Perinatology : Official Journal of the California Perinatal Association
J Meinzen-DerrE F Donovan

Abstract

To determine the association between human milk (HM) intake and risk of necrotizing enterocolitis (NEC) or death among infants 401 to 1000 g birth weight. Analysis of 1272 infants in the National Institute of Child Health and Human Development Neonatal Network Glutamine Trial was performed to determine if increasing HM intake was associated with decreased risk of NEC or death. HM intake was defined as the proportion of HM to total intake, to enteral intake and total volume over the first 14 days. Known NEC risk factors were included as covariates in Cox proportional hazard analyses for duration of survival time free of NEC. Among study infants, 13.6% died or developed NEC after 14 days. The likelihood of NEC or death after 14 days was decreased by a factor of 0.83 (95% confidence interval, CI 0.72, 0.96) for each 10% increase in the proportion of total intake as HM. Each 100 ml kg(-1) increase in HM intake during the first 14 days was associated with decreased risk of NEC or death (hazard ratio, HR 0.87 (95% CI 0.77, 0.97)). There appeared to be a trend towards a decreased risk of NEC or death among infants who received 100% HM as a proportion to total enteral intake (HM plus formula), although this finding was not statisticall...Continue Reading

References

Dec 22, 1990·Lancet·A Lucas, T J Cole
Jan 1, 1994·Acta Paediatrica. Supplement·A M Kosloske
Sep 2, 1998·Pediatrics·M A HylanderR Dhanireddy
Feb 9, 1999·European Journal of Pediatrics·C S PeterC F Poets
Jul 3, 2002·Pediatrics·Jeffrey D HorbarUNKNOWN Members of the Vermont Oxford Network
Dec 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·W McGuire, M Y Anthony
Jan 9, 2003·Archives of Pediatrics & Adolescent Medicine·Lydia FurmanMaureen Hack
May 4, 2004·Pediatrics·Brenda B PoindexterUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Feb 3, 2005·Pediatrics·Lawrence M GartnerUNKNOWN American Academy of Pediatrics Section on Breastfeeding
Dec 2, 2005·Journal of Perinatology : Official Journal of the California Perinatal Association·J T AttridgeP V Gordon
Mar 25, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·Catherine A BoydPeter Brocklehurst
Oct 10, 2006·Lancet·Patricia W Lin, Barbara J Stoll
Apr 20, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·P M SiskT M O'Shea
Jul 4, 2007·Pediatrics·Cherrie D HellerUNKNOWN NICHD Neonatal Research Network

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Citations

Jul 9, 2011·The British Journal of Nutrition·Simon Eaton
Jan 21, 2011·The New England Journal of Medicine·Josef Neu, W Allan Walker
Feb 2, 2010·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Briana J JegierTimothy McBride
Jul 2, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Vaidyanathan GanapathyJae H Kim
Jul 12, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Tina M SlusherMargaret K Nakakeeto
May 23, 2012·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Laura WardUma R Kotagal
Jun 29, 2013·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Jonathan K SeigelMargarita Bidegain
Aug 11, 2010·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Nancy A RodriguezLou Fogg
May 28, 2013·BMC Microbiology·Tonya L WardIllimar Altosaar
May 7, 2010·Journal of Perinatal Medicine·Sertac ArslanogluUNKNOWN World Association of Perinatal Medicine Working Group On Nutrition
Feb 27, 2010·Journal of Perinatal Medicine·Sertac Arslanoglu The Wapm Working Group On Nutrition
Jan 26, 2011·Pediatrics·Camille E PoweCorrine K Welt
Apr 5, 2012·Pediatrics·Coreen L Johnson, James Versalovic
Feb 20, 2013·Pediatrics·Susan M DutySteven Ringer
Feb 15, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·H R BiggerP P Meier
Nov 26, 2013·Seminars in Fetal & Neonatal Medicine·Jae H Kim
Aug 13, 2013·Early Human Development·Enrico BertinoAlessandra Coscia
Mar 22, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·S M GephartJ M McGrath
Mar 5, 2014·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Kenneth Herrmann, Katherine Carroll
Sep 5, 2013·Early Human Development·Ali Faraghi Ahrabi, Richard J Schanler
May 27, 2014·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Sheila M GephartBrittany Krisman
May 24, 2014·Journal of Pediatric Surgery·Dhriti MukhopadhyayLena Perger
Sep 4, 2013·Early Human Development·Jae H KimLisa M Stellwagen
Jul 22, 2014·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Julie WagnerAnn Anderson-Berry
Jul 26, 2014·Analytical and Bioanalytical Chemistry·L Renee RuhaakCarlito B Lebrilla
May 31, 2014·Clinics in Perinatology·David H Adamkin, Paula G Radmacher
Dec 3, 2014·Clinics in Perinatology·Josef Neu
Jul 11, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·A L PatelJ M Silvestri
Oct 3, 2013·Journal of Pediatric Gastroenterology and Nutrition· Johannes van Goudoever
Aug 7, 2012·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Leslie A ParkerMartina Mueller
Sep 12, 2012·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Lorraine Kelley
Sep 15, 2010·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Sarah N TaylorDarrin Bizal
Sep 18, 2013·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Leslie A Parker
Sep 18, 2013·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Phyllis Lawlor-KleanJeanne Wiesbrock
Apr 25, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Cheryl A MinerRobert D Christensen
Jun 6, 2014·Expert Review of Clinical Immunology·Misty GoodDavid J Hackam
Jul 22, 2014·FEBS Letters·Sharon M DonovanRobert S Chapkin
Sep 26, 2015·International Journal of Surgery·Kyuwhan JungSung-Eun Jung

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