Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders

Archives of Cardiovascular Diseases
L RochetteCatherine Vergely

Abstract

The mitochondria produce specific peptides-mitochondrial-derived peptides-that mediate the transcriptional stress response by their translocation into the nucleus and interaction with deoxyribonucleic acid. Mitochondrial-derived peptides are regulators of metabolism. This class of peptides comprises humanin, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid type c (MOTS-c) and small humanin-like peptides (SHLPs). Humanin inhibits mitochondrial complex 1 activity and limits the level of oxidative stress in the cell. Data show that mitochondrial-derived peptides have a role in improving metabolic diseases, such as type 2 diabetes. Perhaps humanin can be used as a marker for mitochondrial function in cardiovascular disease or as a pharmacological strategy in patients with endothelial dysfunction. The goal of this review is to discuss the newly emerging functions of humanin, and its biological role in cardiovascular disorders.

References

Apr 9, 1981·Nature·S AndersonI G Young
Apr 8, 2004·Molecular Cell·Ronald A Butow, Narayan G Avadhani
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guoguang YingJi Ming Wang
Dec 29, 2004·Cardiovascular Research·Sandrine LecourLionel Opie
May 30, 2009·Genomics·Marek BodziochAldona Dembinska-Kiec
Jul 23, 2009·PloS One·Radhika H MuzumdarPinchas Cohen
Jul 24, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Radhika H MuzumdarDavid J Lefer
Oct 20, 2010·Nature Reviews. Endocrinology·Peter E ClaytonAndrew G Renehan
Oct 22, 2010·Nature·Nick Lane, William Martin
Dec 12, 2012·American Journal of Physiology. Heart and Circulatory Physiology·R J WidmerA Lerman
Aug 30, 2013·Biochemical and Biophysical Research Communications·Laura E KleinRadhika Muzumdar
Jun 7, 2014·Biochimica Et Biophysica Acta·Luc RochetteCatherine Vergely
Sep 23, 2014·Nature Reviews. Molecular Cell Biology·Prashant Mishra, David C Chan
Feb 11, 2015·Apoptosis : an International Journal on Programmed Cell Death·Yue JiaChristina Wang
Nov 19, 2015·Journal of Molecular and Cellular Cardiology·Margaux A Horn, Andrew W Trafford
Feb 13, 2016·Nature Reviews. Cardiology·Luc Rochette, Catherine Vergely
Apr 16, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J XiaoK Yen
Jun 5, 2016·Trends in Biochemical Sciences·Jose I PueyoJuan P Couso
Dec 15, 2016·Mechanisms of Ageing and Development·Giuseppina RoseStefano Salvioli
Jan 26, 2017·Scientific Reports·Maria S NazarenkoValery P Puzyrev
Jun 3, 2017·The Journal of Physiology·Su-Jeong KimKelvin Yen
Dec 19, 2017·Trends in Endocrinology and Metabolism : TEM·Luc RochetteCatherine Vergely
Feb 13, 2018·Biochemical and Biophysical Research Communications·Qingqing QinJundong He
Jun 30, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria ConteStefano Salvioli
Jul 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Qing QinAmir Lerman
Jul 31, 2018·Rejuvenation Research·Andrew R Mendelsohn, James W Larrick
Oct 12, 2018·Journal of Molecular Endocrinology·Hyon-Seung YiMinho Shong
Jun 20, 2019·Frontiers in Endocrinology·Manjunath RamanjaneyaAbdul-Badi Abou-Samra
Aug 23, 2019·American Journal of Physiology. Renal Physiology·Chang LiuFerdinand von Walden
Sep 10, 2019·Frontiers in Cell and Developmental Biology·Ornella MoltedoGiuseppina Amodio
Nov 7, 2019·Molecular & Cellular Oncology·Keisuke Takeda, Shigeru Yanagi
Mar 7, 2020·Basic Research in Cardiology·Amela JusicUNKNOWN EU-CardioRNA COST Action (CA17129)

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Luc RochetteCatherine Vergely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.