Role of hydrogen sulfide in brain synaptic remodeling

Methods in Enzymology
Pradip Kumar KamatNeetu Tyagi

Abstract

Synapses are the functional connection between neurons which are necessary for the transfer of electric activity or chemical activity from one cell to another. Synapses are formed by the pre- and postsynaptic membrane which communicates between pre- and postneurons while a neurochemical modulator is operated in this process. H2S has been known as a toxic gas with rotten eggs smell. However, increasing number of researches show that it regulate a variety of physiological and pathological processes in mammals. Hence, H2S is a physiologically important molecule and has been referred to as the third gaseous molecule alongside carbon monoxide and nitric oxide. The previous era has made an exponential development in the physiological and pathological significance of H2S. Specifically, in the central nervous system, H2S facilitates long-term potentiation and regulates intracellular calcium concentration in brain cells. We as well as others have also shown that H2S has antioxidant, antiapoptotic, and anti-inflammatory properties against various neurodegenerative disorders such as stroke, Alzheimer's disease, and vascular dementia. In this chapter, we highlight the current knowledge of H2S and its neuroprotective effects with a special ...Continue Reading

Citations

Jan 11, 2017·Antioxidants & Redox Signaling·Gopi K KolluruChristopher G Kevil
Feb 10, 2017·Free Radical Biology & Medicine·Leonid LivshitsEinav Gross
Aug 5, 2017·Antioxidants·Gethin J McBean
Dec 12, 2017·Frontiers in Cellular Neuroscience·Aleksey V YakovlevGuzel F Sitdikova
Jun 6, 2020·Journal of Molecular Neuroscience : MN·Jiaxin ZhangMingyang Zhang
Oct 20, 2019·Brain Research·Ray O Bahado-SinghUppala Radhakrishna
Dec 18, 2020·Frontiers in Cellular and Infection Microbiology·Md Aejazur RahmanAdrie J C Steyn
Jan 12, 2021·Oxidative Medicine and Cellular Longevity·Jiaxin ZhangMingyang Zhang
Mar 14, 2021·Pharmacological Reports : PR·Artur PałaszJohn J Worthington
Aug 14, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Takahiro ShimizuMotoaki Saito

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