Role of hydrogen sulfide within the dorsal motor nucleus of the vagus in the control of gastric function in rats

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
H-Z SunH-B Ai

Abstract

Hydrogen sulfide (H2 S) is a gaseous messenger and serves as an important neuromodulator in the central nervous system. This study aimed to clarify the role of H2 S within the dorsal motor nucleus of the vagus (DMV) in the control of gastric function in rats. Cystathionine β-synthetase (CBS) is an important generator of endogenous H2 S in the brain. We investigated the distribution of CBS in the DMV using immunohistochemical method, and the effects of H2 S on gastric motility and on gastric acid secretion. CBS-immunoreactive (IR) neurons were detected in the rostral, intermediate and caudal DMV, with the highest number of CBS-IR neurons in the caudal DMV, and the lowest in the intermediate DMV. We also found that microinjection of the exogenous H2 S donor NaHS (0.04 and 0.08 mol/L; 0.1 μL; n = 6; p < 0.05) into the DMV significantly inhibited gastric motility with a dose-dependent trend, and promoted gastric acid secretion in Wistar rats. Microinjection of the same volume of physiological saline (PS; 0.1 μL, n = 6, p > 0.05) at the same location did not noticeably change gastric motility and acid secretion. The data from these experiments suggest that the CBS that produces H2 S is present in the DMV, and microinjection of NaHS ...Continue Reading

References

Jan 1, 1987·Methods in Enzymology·O W Griffith
Dec 2, 1999·Journal of the Autonomic Nervous System·Z K KrowickiP J Hornby
Jan 7, 2000·Biochemical and Biophysical Research Communications·H Kimura
Aug 10, 2000·The Journal of Comparative Neurology·Z Cheng, T L Powley
May 24, 2006·World Journal of Gastroenterology : WJG·Xue-Ying ZhangXi-Yun Cui
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maureen T CruzRichard A Gillis
Jul 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bin GengJunbao Du
Nov 22, 2007·The Journal of Pharmacology and Experimental Therapeutics·George D WebbPhilip K Moore
May 8, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shi-Yi ZhouChung Owyang
May 17, 2008·Life Sciences·Zhifang FuChaoshu Tang
Jun 6, 2009·The Journal of Pharmacology and Experimental Therapeutics·Jand Venes R MedeirosMarcellus H L P Souza
Oct 27, 2009·Antioxidants & Redox Signaling·Yuka KimuraHideo Kimura
Aug 6, 2010·Vascular Pharmacology·Sagiraju SowmyaMadhav Bhatia
Jan 14, 2011·Blood Purification·Alessandra F PernaDiego Ingrosso
Jul 8, 2011·Journal of Neurophysiology·James R AustgenDavid D Kline
Feb 4, 2012·Current Medicinal Chemistry·K TakeuchiS Hayashi
Jul 12, 2012·Nature Reviews. Molecular Cell Biology·Bindu D Paul, Solomon H Snyder
Jan 24, 2013·Nature Communications·Norihiro ShibuyaHideo Kimura
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tomoaki IdaTakaaki Akaike

❮ Previous
Next ❯

Citations

Aug 28, 2021·Journal of Clinical Medicine·Oscar McCookTamara Merz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.