Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats.

International Journal of Experimental Pathology
I-Min LiuJuei-Tang Cheng

Abstract

The role of hyperglycaemia in the pathogenesis of hypotension in diabetic disorders was investigated using the changes in cardiac M(2)-muscarinic receptor (M(2)-mAChR) gene expression in type-1-like diabetic rats and cultured cardiomyocytes. Blood pressure was markedly decreased in diabetic rats following the intravenous injection of streptozotocin (STZ) for 8 weeks. Also, the baroreflex sensitivity (Delta HR/Delta BP), as measured by the changes in heart rate (Delta HR) and mean blood pressure (Delta BP) 1 min after the intravenous injection of phenylephrine (10 microg/kg), was significantly increased. Arecaidine propargyl ester (APE), a M(2)-mAChR agonist produced a marked reduction in heart rate in these diabetic rats. Normalization of plasma glucose in diabetic rats using insulin (0.5 IU) or phlorizin (1 mg/kg) injection attenuated the blood pressure reduction and reversed the mRNA and protein levels of cardiac M(2)-mAChR. A high concentration of glucose (20 mmol/l) directly influenced the increase in gene expression of M(2)-mAChR in the H9c2 cardiac cell line. Hyperglycaemia induced an increase in cardiac M(2)-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders.

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Citations

Mar 20, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Lovisa NalinMarianne Jensen-Waern
Jul 5, 2012·Archives of Physiology and Biochemistry·César Eduardo Jacintho MoritzEmerson André Casali
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Nov 17, 2009·Autonomic Neuroscience : Basic & Clinical·Min LinZixi Jack Cheng

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