PMID: 9538625Apr 16, 1998Paper

Role of hyperinsulinemia and glucose intolerance in the pathogenesis of nonalcoholic fatty liver in patients with normal body weight

The Korean Journal of Internal Medicine
J H LeeK W Choi

Abstract

The pathogenesis of nonalcoholic fatty liver in non-obese persons is poorly understood. We aimed to elucidate whether hyperinsulinemia and glucose intolerance are associated with development of fatty liver in patients with normal body weight. Forty-seven patients with fatty liver were divided into non-obese (n = 25) and obese groups (n = 22) according to age adjusted body mass index. Inclusion criteria were as follows: (1) elevated transaminase levels during more than 3 months of follow up period, (2) no detectable HBsAg or anti-HCV in the serum, (3) alcohol consumption less than 40 gm/week, (4) no use of potential hepatotoxic drugs within 3 months and (4) sonographic evidence of fatty liver(moderate to severe degree). Baseline insulin levels and oral glucose tolerance test using 75gm of glucose were performed and the results were compared in each group of patients. Mean baseline insulin levels were elevated in both groups above the reference value, 9.3 +/- 3.5 microU/L in non-obese group and 9.9 +/- 3.5 microU/L in obese group (p = 0.26). Seventeen of non-obese patients (68%) had elevated basal insulin level and 16 of obese patients (73%) had elevated basal insulin level (p = 0.39). In oral glucose tolerance test, there was no...Continue Reading

References

Jul 1, 1979·AJR. American Journal of Roentgenology·B B GosinkG R Leopold
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R Wanless, J S Lentz
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellL W Powell
Feb 1, 1985·Gut·A BraillonC Quenum
Feb 1, 1985·Histopathology·P A Batman, P J Scheuer
Jan 1, 1980·Annual Review of Biochemistry·J D McGarry, D W Foster
May 1, 1980·The British Journal of Radiology·K J FosterR Wright

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Citations

Nov 24, 1999·The American Journal of Medicine·G MarchesiniN Melchionda
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Chih-Wen WangWan-Long Chuang
Oct 13, 2009·Journal of Gastroenterology and Hepatology·Tamaki YamadaTakashi Joh
May 16, 2006·Gastroenterology·Philippe MathurinFrançois Pattou
Mar 7, 2009·World Journal of Gastroenterology : WJG·Hüseyin Saadettin UslusoyZeynep Biyikli
Sep 9, 2005·World Journal of Gastroenterology : WJG·Hyeon-Chang KimDae-Jung Kim
May 3, 2016·Therapeutic Advances in Gastroenterology·Shira Zelber-SagiFederico Salomone
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Abhimanyu Garg, Anoop Misra

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