Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications

Seminars in Reproductive Endocrinology
John E Nestler

Abstract

The polycystic ovary syndrome (PCOS) is a prevalent disorder affecting approximately 6% of women of reproductive age, and is characterized by anovulation and hyperandrogenism. It has also become apparent that a frequent feature of women with PCOS is insulin resistance accompanied by compensatory hyperinsulinemia, and increasing evidence suggests that hyperinsulinemia plays an important role in the pathogenesis of PCOS. This article will review (1) evidence indicating that insulin contributes to the hyperandrogenism of PCOS by stimulating ovarian androgen production and decreasing serum sex hormone-binding globulin (SHBG) concentrations; (2) possible direct effects of hyperinsulinemia on folliculogenesis; (3) the relationship between insulin and adrenal androgens in women; and (4) therapeutic and clinical implications of these findings.

Citations

Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Jun 3, 1999·Endocrinology and Metabolism Clinics of North America·L C Giudice
Jan 28, 2003·Journal of Pediatric and Adolescent Gynecology·Elisabeth H Quint
Mar 20, 2008·Reproductive Biology and Endocrinology : RB&E·John D BrannianMaureen Diggins
Apr 1, 2008·Human Reproduction·Jean-Patrice BaillargeonEvanthia Diamanti-Kandarakis
Oct 16, 2009·Human Reproduction·Lauren A WiseElizabeth E Hatch
Apr 7, 2010·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Kai I CheangJohn E Nestler
Jan 4, 2008·The New England Journal of Medicine·John E Nestler
Sep 5, 2003·Archives of Gynecology and Obstetrics·Majedah Al-AzemiAlexander E Omu
Sep 17, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H S QublanN Al-Ahmad
Dec 15, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nicolas GalazisWilliam Atiomo
Aug 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Namrata Ajaykumar Desai, Snehal S Patel
Jul 16, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·John E Nestler, Vittorio Unfer
Dec 31, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·L Ferreira SantanaR M dos Reis
Oct 22, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Muzaffer TemurHüseyin Anıl Korkmaz
Oct 3, 1999·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·M E Rousseau
Dec 6, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Nicolas GalazisWilliam Atiomo
Apr 12, 2007·Reproductive Biomedicine Online·Franz Geisthövel, Thomas Rabe
Oct 15, 2005·Pediatric Annals·Amy Fleischman, Joan Mansfield
Nov 26, 2008·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Dec 4, 2015·Mass Spectrometry Reviews·Huiliang YangYuquan Wei
Dec 3, 2003·Annals of the New York Academy of Sciences·Jerome F Strauss
Sep 8, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Barbara MlinarMarija Pfeifer
Dec 13, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Manuel Luque-RamírezHéctor F Escobar-Morreale
Mar 3, 2001·American Journal of Obstetrics and Gynecology·S KorhonenS Saarikoski
Oct 9, 2016·Reproductive Biomedicine Online·Alessandro D Genazzani
Feb 17, 2017·Biology of Reproduction·Jacob S RobertsNatalia Toporikova
Apr 6, 2017·Molecular Reproduction and Development·Debabrata Das, Swathi Arur
Dec 17, 1998·American Journal of Obstetrics and Gynecology·S L Berga
Aug 11, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Brenda BrunerDonna Chizen

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