Abstract
To determine whether hypo-osmotic saline drops can improve contact lens associated discomfort and dryness by decreasing contact lens osmolality. Fifteen symptomatic subjects wore Lotrafilcon A lenses bilaterally for 6h on two different days. According to randomisation, hypo-osmotic (280mmol/kg) or hyper-osmotic (380mmol/kg) saline drops were applied four times during each day and ocular symptoms, tear film and contact lens parameters, and contact lens osmolality were assessed. Sixty percent of the subjects preferred the hypo-osmotic saline drops, compared to 33%, who preferred the hyper-osmotic ones. Subjects experienced significantly less dryness and lens awareness with hypo-osmotic saline drops compared to hyper-osmotic ones (p<0.05). Using the hypo-osmotic drops, there was a trend for decreased contact lens osmolality from 379 to 343mmol/kg (p=0.06). There were no differences in lipid layer, non-invasive tear film break-up time, lens surface wettability, lens water content after wear, lens movement on eye or ocular staining and indentation between saline drops (all p>0.05). Interestingly, the difference in contact lens osmolality between drops did not reflect the osmolality difference between the two saline drops. Hypo-osmot...Continue Reading
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