PMID: 7008061Dec 1, 1980Paper

Role of hypotension induced by PGI2 on the control of depth and frequency of breathing

Prostaglandins and Medicine
M G ClementG Aguggini

Abstract

We studied the respiratory response to infusion of prostacyclin (PGI2) in 7 anaesthetized pigs in an attempt to understand whether the changes in pattern of breathing were due to a direct action of the substance or to the concomitant hypotensive effect. The depth and frequency of breathing were analyzed in terms of the threshold-inhibition curve for termination of inspiration (VT/TI relationship) and of bulbo-pontine rhythm, estimated from inspiratory and expiratory time during occlusion of the airways at the end expiratory level (TE/TI relationship). This provide the central respiratory rhythm when the phasic lung volume receives no input from pulmonary stretch receptors. The hypotension induced by PGI2 increased pulmonary ventilation mainly through a change in VT and caused a slight rightward displacement of VT/TI relationship without modifying the slope of the curve. This effect seems to be vagally mediated. PGI2 also changed the bulbo-pontine rhythm. Our results show that PGI2 modifies the vagal discharge and bulbo-pontine rhythm by two opposite mechanisms: hypotension and an apparent direct action on carotid and aortic baroreceptors.

References

Jun 29, 1978·Nature·S MoncadaJ R Vane
Aug 24, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·R J GryglewskiJ Swies
Jul 1, 1981·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·M G ClementG Miserocchi

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